Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes

Interleukin-1β (IL-1β) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1β by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also...

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Detalles Bibliográficos
Autores principales: Antonopoulos, Christina, Dubyak, George R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006851/
https://www.ncbi.nlm.nih.gov/pubmed/24800164
http://dx.doi.org/10.4161/onci.27499
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author Antonopoulos, Christina
Dubyak, George R
author_facet Antonopoulos, Christina
Dubyak, George R
author_sort Antonopoulos, Christina
collection PubMed
description Interleukin-1β (IL-1β) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1β by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also trigger the secretion of IL-1β by driving the assembly of the caspase-8- and FADD-containing platform known as the ripoptosome.
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spelling pubmed-40068512014-05-05 Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes Antonopoulos, Christina Dubyak, George R Oncoimmunology Author's View Interleukin-1β (IL-1β) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1β by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also trigger the secretion of IL-1β by driving the assembly of the caspase-8- and FADD-containing platform known as the ripoptosome. Landes Bioscience 2014-01-03 /pmc/articles/PMC4006851/ /pubmed/24800164 http://dx.doi.org/10.4161/onci.27499 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Antonopoulos, Christina
Dubyak, George R
Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
title Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
title_full Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
title_fullStr Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
title_full_unstemmed Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
title_short Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes
title_sort chemotherapy engages multiple pathways leading to il-1β production by myeloid leukocytes
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006851/
https://www.ncbi.nlm.nih.gov/pubmed/24800164
http://dx.doi.org/10.4161/onci.27499
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AT dubyakgeorger chemotherapyengagesmultiplepathwaysleadingtoil1bproductionbymyeloidleukocytes

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