Role of the complement system in NK cell-mediated antitumor T-cell responses

The role of the complement system in oncogenesis and tumor progression remains poorly understood. We have recently demonstrated that the induction of a tumor-specific CD8(+) T-cell response is improved upon transient inhibition of the complement system, which is coupled to an increased availability...

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Detalles Bibliográficos
Autores principales: Janelle, Valérie, Lamarre, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006857/
https://www.ncbi.nlm.nih.gov/pubmed/24800174
http://dx.doi.org/10.4161/onci.27897
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author Janelle, Valérie
Lamarre, Alain
author_facet Janelle, Valérie
Lamarre, Alain
author_sort Janelle, Valérie
collection PubMed
description The role of the complement system in oncogenesis and tumor progression remains poorly understood. We have recently demonstrated that the induction of a tumor-specific CD8(+) T-cell response is improved upon transient inhibition of the complement system, which is coupled to an increased availability of natural killer cells. The complement system may therefore turn out to constitute a promising target for the development of novel anticancer therapeutics.
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spelling pubmed-40068572015-02-14 Role of the complement system in NK cell-mediated antitumor T-cell responses Janelle, Valérie Lamarre, Alain Oncoimmunology Author's View The role of the complement system in oncogenesis and tumor progression remains poorly understood. We have recently demonstrated that the induction of a tumor-specific CD8(+) T-cell response is improved upon transient inhibition of the complement system, which is coupled to an increased availability of natural killer cells. The complement system may therefore turn out to constitute a promising target for the development of novel anticancer therapeutics. Landes Bioscience 2014-02-14 /pmc/articles/PMC4006857/ /pubmed/24800174 http://dx.doi.org/10.4161/onci.27897 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Janelle, Valérie
Lamarre, Alain
Role of the complement system in NK cell-mediated antitumor T-cell responses
title Role of the complement system in NK cell-mediated antitumor T-cell responses
title_full Role of the complement system in NK cell-mediated antitumor T-cell responses
title_fullStr Role of the complement system in NK cell-mediated antitumor T-cell responses
title_full_unstemmed Role of the complement system in NK cell-mediated antitumor T-cell responses
title_short Role of the complement system in NK cell-mediated antitumor T-cell responses
title_sort role of the complement system in nk cell-mediated antitumor t-cell responses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006857/
https://www.ncbi.nlm.nih.gov/pubmed/24800174
http://dx.doi.org/10.4161/onci.27897
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AT lamarrealain roleofthecomplementsysteminnkcellmediatedantitumortcellresponses

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