Wise Regulates Bone Deposition through Genetic Interactions with Lrp5

In this study using genetic approaches in mouse we demonstrate that the secreted protein Wise plays essential roles in regulating early bone formation through its ability to modulate Wnt signaling via interactions with the Lrp5 co-receptor. In Wise(−/−) mutant mice we find an increase in the rate of...

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Detalles Bibliográficos
Autores principales: Ellies, Debra L., Economou, Androulla, Viviano, Beth, Rey, Jean-Philippe, Paine-Saunders, Stephenie, Krumlauf, Robb, Saunders, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006890/
https://www.ncbi.nlm.nih.gov/pubmed/24789067
http://dx.doi.org/10.1371/journal.pone.0096257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006890/
https://www.ncbi.nlm.nih.gov/pubmed/24789067
http://dx.doi.org/10.1371/journal.pone.0096257

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