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Wise Regulates Bone Deposition through Genetic Interactions with Lrp5
In this study using genetic approaches in mouse we demonstrate that the secreted protein Wise plays essential roles in regulating early bone formation through its ability to modulate Wnt signaling via interactions with the Lrp5 co-receptor. In Wise(−/−) mutant mice we find an increase in the rate of...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006890/ https://www.ncbi.nlm.nih.gov/pubmed/24789067 http://dx.doi.org/10.1371/journal.pone.0096257 |