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Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (HTT) protein. The expression of mutant HTT in the baker’s yeast Saccharomyces cerevisiae recapitulates many of the cellular phenotypes observed in mammalian HD models. Mutant H...

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Detalles Bibliográficos
Autores principales:	Kantcheva, Ralitsa B., Mason, Robert, Giorgini, Flaviano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Molecular/Cellular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006944/ https://www.ncbi.nlm.nih.gov/pubmed/24804153 http://dx.doi.org/10.1371/currents.hd.501008f3051342c9a5c0cd0f3a5bf3a4

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