Cargando…

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α(1)-antitrypsin

Overexpression of Z α(1)-antitrypsin is known to induce polymer formation, prime the cells for endoplasmic reticulum stress and initiate nuclear factor kappa B (NF-κB) signalling. However, whether endogenous expression in primary bronchial epithelial cells has similar consequences remains unclear. M...

Descripción completa

Detalles Bibliográficos
Autores principales:	van ‘t Wout, Emily F.A., Dickens, Jennifer A., van Schadewijk, Annemarie, Haq, Imran, Kwok, Hang Fai, Ordóñez, Adriana, Murphy, Gillian, Stolk, Jan, Lomas, David A., Hiemstra, Pieter S., Marciniak, Stefan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007119/ https://www.ncbi.nlm.nih.gov/pubmed/24097797 http://dx.doi.org/10.1093/hmg/ddt487

Ejemplares similares

A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress
por: van Schadewijk, Annemarie, et al.
Publicado: (2011)

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α(1)-antitrypsin while allowing its antiproteinase activity
por: Ordóñez, Adriana, et al.
Publicado: (2015)

Altered native stability is the dominant basis for susceptibility of α(1)-antitrypsin mutants to polymerization
por: Irving, James A., et al.
Publicado: (2014)

The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α(1)-antitrypsin
por: Dickens, Jennifer A., et al.
Publicado: (2016)

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway
por: Haq, Imran, et al.
Publicado: (2013)

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway
por: Haq, Imran, et al.
Publicado: (2013)

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody
por: Tan, Lu, et al.
Publicado: (2015)

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells
por: van ‘t Wout, Emily F. A., et al.
Publicado: (2015)

Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant
por: Dickens, Jennifer A., et al.
Publicado: (2022)

Development of a small molecule that corrects misfolding and increases secretion of Z α(1)‐antitrypsin
por: Lomas, David A, et al.
Publicado: (2021)

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin
por: Laffranchi, Mattia, et al.
Publicado: (2020)

High-resolution ex vivo NMR spectroscopy of human Z α(1)-antitrypsin
por: Jagger, Alistair M., et al.
Publicado: (2020)

Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation
por: Khedoe, P. P. S. J., et al.
Publicado: (2023)

Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis
por: Dickens, Jennifer A, et al.
Publicado: (2011)

Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells
por: Wang, Ying, et al.
Publicado: (2020)

The structural basis for Z α(1)-antitrypsin polymerization in the liver
por: Faull, Sarah V., et al.
Publicado: (2020)

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin
por: Malintan, Nancy T., et al.
Publicado: (2019)

Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures
por: van Riet, Sander, et al.
Publicado: (2022)

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency
por: Pini, Laura, et al.
Publicado: (2014)

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
por: Ordóñez, Adriana, et al.
Publicado: (2021)

Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency
por: Stolk, Jan, et al.
Publicado: (2005)

Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae
por: Zarcone, Maria C., et al.
Publicado: (2017)

Alpha-1-Antitrypsin Deficiency, the Serpinopathies and Conformational Disease
por: Parmar, Jas S, et al.
Publicado: (2000)

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients
por: Schouten, Iris G. M., et al.
Publicado: (2021)

Association of Lung Inflammatory Cells with Small Airways Function and Exhaled Breath Markers in Smokers – Is There a Specific Role for Mast Cells?
por: Nussbaumer-Ochsner, Yvonne, et al.
Publicado: (2015)

The pathological Trento variant of alpha‐1‐antitrypsin (E75V) shows nonclassical behaviour during polymerization
por: Miranda, Elena, et al.
Publicado: (2017)

Stem cell-based therapy for α(1)-antitrypsin deficiency
por: Rashid, S Tamir, et al.
Publicado: (2012)

Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo
por: Kunz, L. I. Z., et al.
Publicado: (2015)

Correction: Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency
por: Stolk, Jan, et al.
Publicado: (2006)

Hereditary alpha-1-antitrypsin deficiency and its clinical consequences
por: Fregonese, Laura, et al.
Publicado: (2008)

Z-α(1)-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state
por: Chambers, Joseph E., et al.
Publicado: (2022)

Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization
por: Berthelier, Valerie, et al.
Publicado: (2015)

Molecular Mechanism of Z α1-Antitrypsin Deficiency
por: Huang, Xin, et al.
Publicado: (2016)

Targeted gene correction of α(1)-antitrypsin deficiency in induced pluripotent stem cells
por: Yusa, Kosuke, et al.
Publicado: (2011)

The Z Mutation Alters the Global Structural Dynamics of α(1)-Antitrypsin
por: Hughes, Victoria A., et al.
Publicado: (2014)

Alpha(1)-antitrypsin deficiency: current perspective on research, diagnosis, and management
por: Stolk, Jan, et al.
Publicado: (2006)

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients
por: Sark, Annelot D., et al.
Publicado: (2022)

Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D(3) as host directed therapy
por: Rekha, Rokeya Sultana, et al.
Publicado: (2018)

ATZ11 Recognizes Not Only Z-α(1)-Antitrypsin-Polymers and Complexed Forms of Non-Z-α(1)-Antitrypsin but Also the von Willebrand Factor
por: Goltz, Diane, et al.
Publicado: (2014)

Risk factors for symptom onset in PI*Z alpha-1 antitrypsin deficiency
por: Mayer, Annyce S, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_of0le6l42r7flu7nna8uj6ee8f