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Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas
BACKGROUND: Kinase module of Mediator complex (‘CDK8 submodule') consists of four subunits: CDK8, Cyclin C, MED12, and MED13. Recently, we reported recurrent MED12 mutations in 70% of uterine leiomyomas. The aim of this study was to analyse whether mutations in other components of the module co...
Autores principales: | Mäkinen, N, Heinonen, H-R, Sjöberg, J, Taipale, J, Vahteristo, P, Aaltonen, L A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007231/ https://www.ncbi.nlm.nih.gov/pubmed/24642626 http://dx.doi.org/10.1038/bjc.2014.138 |
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