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Evaluation of Nanodispersion of Iron Oxides Using Various Polymers

In order to create Fe(2)O(3) and Fe(2)O(3)·H(2)O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length...

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Autores principales: Tanaka, Y., Ueyama, H., Ogata, M., Daikoku, T., Morimoto, M., Kitagawa, A., Imajo, Y., Tahara, T., Inkyo, M., Yamaguchi, N., Nagata, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007256/
https://www.ncbi.nlm.nih.gov/pubmed/24799739
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author Tanaka, Y.
Ueyama, H.
Ogata, M.
Daikoku, T.
Morimoto, M.
Kitagawa, A.
Imajo, Y.
Tahara, T.
Inkyo, M.
Yamaguchi, N.
Nagata, S.
author_facet Tanaka, Y.
Ueyama, H.
Ogata, M.
Daikoku, T.
Morimoto, M.
Kitagawa, A.
Imajo, Y.
Tahara, T.
Inkyo, M.
Yamaguchi, N.
Nagata, S.
author_sort Tanaka, Y.
collection PubMed
description In order to create Fe(2)O(3) and Fe(2)O(3)·H(2)O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe(2)O(3) and Fe(2)O(3)·H(2)O particles. Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe(2)O(3) nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill. Fe(2)O(3)·H(2)O nanoparticles could also be produced using 5.0% hydroxypropylcellulose-SSL and 4.0 and 7.0% Pharmacoat 904. The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.
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spelling pubmed-40072562014-05-05 Evaluation of Nanodispersion of Iron Oxides Using Various Polymers Tanaka, Y. Ueyama, H. Ogata, M. Daikoku, T. Morimoto, M. Kitagawa, A. Imajo, Y. Tahara, T. Inkyo, M. Yamaguchi, N. Nagata, S. Indian J Pharm Sci Research Paper In order to create Fe(2)O(3) and Fe(2)O(3)·H(2)O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe(2)O(3) and Fe(2)O(3)·H(2)O particles. Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe(2)O(3) nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill. Fe(2)O(3)·H(2)O nanoparticles could also be produced using 5.0% hydroxypropylcellulose-SSL and 4.0 and 7.0% Pharmacoat 904. The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4007256/ /pubmed/24799739 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Tanaka, Y.
Ueyama, H.
Ogata, M.
Daikoku, T.
Morimoto, M.
Kitagawa, A.
Imajo, Y.
Tahara, T.
Inkyo, M.
Yamaguchi, N.
Nagata, S.
Evaluation of Nanodispersion of Iron Oxides Using Various Polymers
title Evaluation of Nanodispersion of Iron Oxides Using Various Polymers
title_full Evaluation of Nanodispersion of Iron Oxides Using Various Polymers
title_fullStr Evaluation of Nanodispersion of Iron Oxides Using Various Polymers
title_full_unstemmed Evaluation of Nanodispersion of Iron Oxides Using Various Polymers
title_short Evaluation of Nanodispersion of Iron Oxides Using Various Polymers
title_sort evaluation of nanodispersion of iron oxides using various polymers
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007256/
https://www.ncbi.nlm.nih.gov/pubmed/24799739
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