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Preparation and Characterisation of Nevirapine Oral Nanosuspensions
The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solub...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007257/ https://www.ncbi.nlm.nih.gov/pubmed/24799740 |
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author | Raju, Anju Reddy, A. Jagdeesh Satheesh, J. Jithan, A. V. |
author_facet | Raju, Anju Reddy, A. Jagdeesh Satheesh, J. Jithan, A. V. |
author_sort | Raju, Anju |
collection | PubMed |
description | The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can overcome the oral bioavailability problem of nevirapine. Nevirapine nanosuspensions were prepared using nanoedge method. The suspensions were stabilised using surfactants Lutrol F 127 or Poloxamer 407 and hydroxypropyl methyl cellulose. The nanosuspension was characterised for particle size, polydispersibility index, crystalline state, particle morphology, in vitro drug release and pharmacokinetics in rats after oral administration. The results support the claim for the preparation of nanosuspensions with enhanced solubility and bioavailability. |
format | Online Article Text |
id | pubmed-4007257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40072572014-05-05 Preparation and Characterisation of Nevirapine Oral Nanosuspensions Raju, Anju Reddy, A. Jagdeesh Satheesh, J. Jithan, A. V. Indian J Pharm Sci Research Paper The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can overcome the oral bioavailability problem of nevirapine. Nevirapine nanosuspensions were prepared using nanoedge method. The suspensions were stabilised using surfactants Lutrol F 127 or Poloxamer 407 and hydroxypropyl methyl cellulose. The nanosuspension was characterised for particle size, polydispersibility index, crystalline state, particle morphology, in vitro drug release and pharmacokinetics in rats after oral administration. The results support the claim for the preparation of nanosuspensions with enhanced solubility and bioavailability. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4007257/ /pubmed/24799740 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Raju, Anju Reddy, A. Jagdeesh Satheesh, J. Jithan, A. V. Preparation and Characterisation of Nevirapine Oral Nanosuspensions |
title | Preparation and Characterisation of Nevirapine Oral Nanosuspensions |
title_full | Preparation and Characterisation of Nevirapine Oral Nanosuspensions |
title_fullStr | Preparation and Characterisation of Nevirapine Oral Nanosuspensions |
title_full_unstemmed | Preparation and Characterisation of Nevirapine Oral Nanosuspensions |
title_short | Preparation and Characterisation of Nevirapine Oral Nanosuspensions |
title_sort | preparation and characterisation of nevirapine oral nanosuspensions |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007257/ https://www.ncbi.nlm.nih.gov/pubmed/24799740 |
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