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Preparation and Characterisation of Nevirapine Oral Nanosuspensions

The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solub...

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Autores principales: Raju, Anju, Reddy, A. Jagdeesh, Satheesh, J., Jithan, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007257/
https://www.ncbi.nlm.nih.gov/pubmed/24799740
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author Raju, Anju
Reddy, A. Jagdeesh
Satheesh, J.
Jithan, A. V.
author_facet Raju, Anju
Reddy, A. Jagdeesh
Satheesh, J.
Jithan, A. V.
author_sort Raju, Anju
collection PubMed
description The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can overcome the oral bioavailability problem of nevirapine. Nevirapine nanosuspensions were prepared using nanoedge method. The suspensions were stabilised using surfactants Lutrol F 127 or Poloxamer 407 and hydroxypropyl methyl cellulose. The nanosuspension was characterised for particle size, polydispersibility index, crystalline state, particle morphology, in vitro drug release and pharmacokinetics in rats after oral administration. The results support the claim for the preparation of nanosuspensions with enhanced solubility and bioavailability.
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spelling pubmed-40072572014-05-05 Preparation and Characterisation of Nevirapine Oral Nanosuspensions Raju, Anju Reddy, A. Jagdeesh Satheesh, J. Jithan, A. V. Indian J Pharm Sci Research Paper The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can overcome the oral bioavailability problem of nevirapine. Nevirapine nanosuspensions were prepared using nanoedge method. The suspensions were stabilised using surfactants Lutrol F 127 or Poloxamer 407 and hydroxypropyl methyl cellulose. The nanosuspension was characterised for particle size, polydispersibility index, crystalline state, particle morphology, in vitro drug release and pharmacokinetics in rats after oral administration. The results support the claim for the preparation of nanosuspensions with enhanced solubility and bioavailability. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4007257/ /pubmed/24799740 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Raju, Anju
Reddy, A. Jagdeesh
Satheesh, J.
Jithan, A. V.
Preparation and Characterisation of Nevirapine Oral Nanosuspensions
title Preparation and Characterisation of Nevirapine Oral Nanosuspensions
title_full Preparation and Characterisation of Nevirapine Oral Nanosuspensions
title_fullStr Preparation and Characterisation of Nevirapine Oral Nanosuspensions
title_full_unstemmed Preparation and Characterisation of Nevirapine Oral Nanosuspensions
title_short Preparation and Characterisation of Nevirapine Oral Nanosuspensions
title_sort preparation and characterisation of nevirapine oral nanosuspensions
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007257/
https://www.ncbi.nlm.nih.gov/pubmed/24799740
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