Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents

A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular act...

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Autores principales: Shashiprabha, Nayak, S. P., Rao, K. Sundarraja, Nagarajan, K., Shridhara, K., Torreele, E., Trunz, B. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007262/
https://www.ncbi.nlm.nih.gov/pubmed/24799745
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author Shashiprabha,
Nayak, S. P.
Rao, K. Sundarraja
Nagarajan, K.
Shridhara, K.
Torreele, E.
Trunz, B. B.
author_facet Shashiprabha,
Nayak, S. P.
Rao, K. Sundarraja
Nagarajan, K.
Shridhara, K.
Torreele, E.
Trunz, B. B.
author_sort Shashiprabha,
collection PubMed
description A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular activity, particularly CGI17341 (5a). In the present study (5a) and (5d) and (7) were found to be more potent antileishmanials in vitro than the standard and less toxic in relation to a reference compound. (7) Was earlier formulated to have the phenyl group located on C-2(5b).
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spelling pubmed-40072622014-05-05 Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents Shashiprabha, Nayak, S. P. Rao, K. Sundarraja Nagarajan, K. Shridhara, K. Torreele, E. Trunz, B. B. Indian J Pharm Sci Short Communication A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular activity, particularly CGI17341 (5a). In the present study (5a) and (5d) and (7) were found to be more potent antileishmanials in vitro than the standard and less toxic in relation to a reference compound. (7) Was earlier formulated to have the phenyl group located on C-2(5b). Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4007262/ /pubmed/24799745 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Shashiprabha,
Nayak, S. P.
Rao, K. Sundarraja
Nagarajan, K.
Shridhara, K.
Torreele, E.
Trunz, B. B.
Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents
title Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents
title_full Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents
title_fullStr Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents
title_full_unstemmed Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents
title_short Nitroimidazooxazoles(#) Part xxiv, Search for Antileishmanial Agents: 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles as Potential Antileishmanial Agents
title_sort nitroimidazooxazoles(#) part xxiv, search for antileishmanial agents: 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles as potential antileishmanial agents
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007262/
https://www.ncbi.nlm.nih.gov/pubmed/24799745
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