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The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction
INTRODUCTION: Insulin-like growth factor-1 (IGF-1) has atheroprotective effects via reduction in oxidative stress, cellular apoptosis, pro-inflammatory signaling, and endothelial dysfunction. AIM: We hypothesized that low levels of IGF-1 may be associated with the severity and extent of coronary art...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007291/ https://www.ncbi.nlm.nih.gov/pubmed/24799921 http://dx.doi.org/10.5114/pwki.2014.41460 |
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author | Akturk, Ibrahim Faruk Yalcin, Ahmet Arif Biyik, Ismail Caglar, Nihan Turhan Isiksacan, Nilgun Sarikamis, Cetin Uzun, Fatih Celik, Omer Caglar, Ilker Murat |
author_facet | Akturk, Ibrahim Faruk Yalcin, Ahmet Arif Biyik, Ismail Caglar, Nihan Turhan Isiksacan, Nilgun Sarikamis, Cetin Uzun, Fatih Celik, Omer Caglar, Ilker Murat |
author_sort | Akturk, Ibrahim Faruk |
collection | PubMed |
description | INTRODUCTION: Insulin-like growth factor-1 (IGF-1) has atheroprotective effects via reduction in oxidative stress, cellular apoptosis, pro-inflammatory signaling, and endothelial dysfunction. AIM: We hypothesized that low levels of IGF-1 may be associated with the severity and extent of coronary artery disease and development of the coronary no-reflow phenomenon in patients with acute ST-elevation myocardial infarction (STEMI) and investigated the role of the IGF-1 molecule in the coronary no-reflow phenomenon and severity of coronary artery disease (CAD) in patients with acute STEMI in a tertiary hospital. MATERIAL AND METHODS: The study was conducted among 113 patients undergoing primary percutaneous coronary intervention (PPCI) for STEMI, of whom 49 patients developed the no-reflow phenomenon. Coronary no-reflow was defined as Thrombolysis In Myocardial Infarction (TIMI) flow grade 2 or less after intervention. Insulin-like growth factor-1 levels were measured in both groups. The severity and extent of CAD were evaluated according to the Gensini and Syntax scores. RESULTS: Although IGF-1 levels were lower in the no-reflow group, there was not a statistically significant difference between the no-reflow group and the control group (116.65 ±51.72 vs. 130.82 ±48.76, p = 0.130). Gensini and Syntax scores were higher in the no-reflow group. There was no association between Gensini and Syntax scores and IGF-1 levels (r = –0.071, r = 0.479, r = –0.158, p = 0.113). CONCLUSIONS: In this study, IGF-1 levels were not statistically different between patients developing the no-reflow phenomenon and controls. There was no association between development of the no-reflow phenomenon and severity of CAD or IGF-1 levels. Nevertheless, large scale studies are needed to verify these results. |
format | Online Article Text |
id | pubmed-4007291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-40072912014-05-05 The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction Akturk, Ibrahim Faruk Yalcin, Ahmet Arif Biyik, Ismail Caglar, Nihan Turhan Isiksacan, Nilgun Sarikamis, Cetin Uzun, Fatih Celik, Omer Caglar, Ilker Murat Postepy Kardiol Interwencyjnej Original Paper INTRODUCTION: Insulin-like growth factor-1 (IGF-1) has atheroprotective effects via reduction in oxidative stress, cellular apoptosis, pro-inflammatory signaling, and endothelial dysfunction. AIM: We hypothesized that low levels of IGF-1 may be associated with the severity and extent of coronary artery disease and development of the coronary no-reflow phenomenon in patients with acute ST-elevation myocardial infarction (STEMI) and investigated the role of the IGF-1 molecule in the coronary no-reflow phenomenon and severity of coronary artery disease (CAD) in patients with acute STEMI in a tertiary hospital. MATERIAL AND METHODS: The study was conducted among 113 patients undergoing primary percutaneous coronary intervention (PPCI) for STEMI, of whom 49 patients developed the no-reflow phenomenon. Coronary no-reflow was defined as Thrombolysis In Myocardial Infarction (TIMI) flow grade 2 or less after intervention. Insulin-like growth factor-1 levels were measured in both groups. The severity and extent of CAD were evaluated according to the Gensini and Syntax scores. RESULTS: Although IGF-1 levels were lower in the no-reflow group, there was not a statistically significant difference between the no-reflow group and the control group (116.65 ±51.72 vs. 130.82 ±48.76, p = 0.130). Gensini and Syntax scores were higher in the no-reflow group. There was no association between Gensini and Syntax scores and IGF-1 levels (r = –0.071, r = 0.479, r = –0.158, p = 0.113). CONCLUSIONS: In this study, IGF-1 levels were not statistically different between patients developing the no-reflow phenomenon and controls. There was no association between development of the no-reflow phenomenon and severity of CAD or IGF-1 levels. Nevertheless, large scale studies are needed to verify these results. Termedia Publishing House 2014-03-23 2014 /pmc/articles/PMC4007291/ /pubmed/24799921 http://dx.doi.org/10.5114/pwki.2014.41460 Text en Copyright © 2014 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Akturk, Ibrahim Faruk Yalcin, Ahmet Arif Biyik, Ismail Caglar, Nihan Turhan Isiksacan, Nilgun Sarikamis, Cetin Uzun, Fatih Celik, Omer Caglar, Ilker Murat The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
title | The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
title_full | The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
title_fullStr | The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
title_full_unstemmed | The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
title_short | The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
title_sort | role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007291/ https://www.ncbi.nlm.nih.gov/pubmed/24799921 http://dx.doi.org/10.5114/pwki.2014.41460 |
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