Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic effect...

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Detalles Bibliográficos
Autores principales: O’Donnell, Kelley C., Lulla, Aaron, Stahl, Mark C., Wheat, Nickolas D., Bronstein, Jeff M., Sagasti, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007408/
https://www.ncbi.nlm.nih.gov/pubmed/24626988
http://dx.doi.org/10.1242/dmm.013185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007408/
https://www.ncbi.nlm.nih.gov/pubmed/24626988
http://dx.doi.org/10.1242/dmm.013185

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