The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding

The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory CC-c...

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Detalles Bibliográficos
Autores principales: Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J. B., Graham, Gerard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007430/
https://www.ncbi.nlm.nih.gov/pubmed/24644289
http://dx.doi.org/10.1074/jbc.M113.534545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007430/
https://www.ncbi.nlm.nih.gov/pubmed/24644289
http://dx.doi.org/10.1074/jbc.M113.534545

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