Cargando…

The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding

The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory CC-c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J. B., Graham, Gerard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007430/ https://www.ncbi.nlm.nih.gov/pubmed/24644289 http://dx.doi.org/10.1074/jbc.M113.534545

Ejemplares similares

The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis
por: Hansell, Christopher A. H., et al.
Publicado: (2018)

Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland
por: Wilson, Gillian J., et al.
Publicado: (2017)

ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology
por: Bonavita, Ornella, et al.
Publicado: (2017)

Corrigendum: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology
por: Bonavita, Ornella, et al.
Publicado: (2017)

MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2
por: Shams, Kave, et al.
Publicado: (2018)

The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density
por: Lee, Kit M, et al.
Publicado: (2014)

D6/ACKR2
por: Graham, Gerard J.
Publicado: (2015)

The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens
por: Hansell, Chris AH, et al.
Publicado: (2015)

The Duffy Antigen Receptor for Chemokines DARC/ACKR1
por: Horuk, Richard
Publicado: (2015)

Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells
por: Hansell, Christopher A.H., et al.
Publicado: (2020)

The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both?
por: Gowhari Shabgah, Arezoo, et al.
Publicado: (2022)

Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5)
por: Bonnavion, Remy, et al.
Publicado: (2023)

Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2
por: Shams, Kave, et al.
Publicado: (2017)

Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings
por: Lewandowska, Paulina, et al.
Publicado: (2020)

A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4
por: Jafarnejad, Mohammad, et al.
Publicado: (2017)

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology
por: Chatterjee, Madhumita
Publicado: (2022)

Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases
por: Duval, Vincent, et al.
Publicado: (2022)

Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response
por: Bonecchi, Raffaella, et al.
Publicado: (2016)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice
por: Zheng, Shirong, et al.
Publicado: (2016)

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis
por: Girbl, Tamara, et al.
Publicado: (2018)

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
por: Meyrath, Max, et al.
Publicado: (2020)

Prospects for targeting ACKR1 in cancer and other diseases
por: Crawford, Kyler S., et al.
Publicado: (2023)

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis
por: Yu, Tian, et al.
Publicado: (2022)

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7
por: Meyrath, Max, et al.
Publicado: (2021)

The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B
por: D’Uonnolo, Giulia, et al.
Publicado: (2022)

Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension
por: Jiang, Chen-Yu, et al.
Publicado: (2023)

Effects of Small Molecule Ligands on ACKR3 Receptors
por: Hopkins, Brittany E., et al.
Publicado: (2022)

The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins
por: Eaton, James R. O., et al.
Publicado: (2018)

Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles
por: Guo, Xinying, et al.
Publicado: (2023)

Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer’s disease risk
por: Murcia, Josue D. Gonzalez, et al.
Publicado: (2020)

Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling
por: Wei, Sung-Tai, et al.
Publicado: (2020)

Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2
por: Vacchini, Alessandro, et al.
Publicado: (2020)

Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model
por: Van Loy, Tom, et al.
Publicado: (2022)

CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6
por: Chevigné, Andy, et al.
Publicado: (2021)

Elevated ACKR2 expression is a common feature of inflammatory arthropathies
por: Baldwin, Helen M., et al.
Publicado: (2017)

Distinct Transcript Isoforms of the Atypical Chemokine Receptor 1 (ACKR1) / Duffy Antigen Receptor for Chemokines (DARC) Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele
por: Davis, Melissa B., et al.
Publicado: (2015)

GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity
por: Melgrati, Serena, et al.
Publicado: (2023)

Structural basis of ligand interaction with atypical chemokine receptor 3
por: Gustavsson, Martin, et al.
Publicado: (2017)

A guide to chemokines and their receptors
por: Hughes, Catherine E., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jhv7f73aripj5gcmohqt74rt4b