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SMAD4 Loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells
BACKGROUND: SMAD4 is a gastrointestinal malignancy-specific tumor suppressor gene found mutated in one third of colorectal cancer specimens and half of pancreatic tumors. SMAD4 inactivation by allelic deletion or intragenic mutation mainly occurs in the late stage of human pancreatic ductal adenocar...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007528/ https://www.ncbi.nlm.nih.gov/pubmed/24625091 http://dx.doi.org/10.1186/1471-2407-14-181 |