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Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

BACKGROUND: The HIV-1 Nef protein is essential for AIDS pathogenesis by its interaction with host cell surface receptors and signaling factors. Despite its critical role as a virulence factor Nef is not targeted by current antiviral strategies. RESULTS: We have determined the crystal structure of th...

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Detalles Bibliográficos
Autores principales:	Lülf, Sebastian, Matz, Julie, Rouyez, Marie-Christine, Järviluoma, Annika, Saksela, Kalle, Benichou, Serge, Geyer, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007562/ https://www.ncbi.nlm.nih.gov/pubmed/24620746 http://dx.doi.org/10.1186/1742-4690-11-24

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