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Assembling evidence for identifying reservoirs of infection

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and...

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Detalles Bibliográficos
Autores principales: Viana, Mafalda, Mancy, Rebecca, Biek, Roman, Cleaveland, Sarah, Cross, Paul C., Lloyd-Smith, James O., Haydon, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007595/
https://www.ncbi.nlm.nih.gov/pubmed/24726345
http://dx.doi.org/10.1016/j.tree.2014.03.002
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author Viana, Mafalda
Mancy, Rebecca
Biek, Roman
Cleaveland, Sarah
Cross, Paul C.
Lloyd-Smith, James O.
Haydon, Daniel T.
author_facet Viana, Mafalda
Mancy, Rebecca
Biek, Roman
Cleaveland, Sarah
Cross, Paul C.
Lloyd-Smith, James O.
Haydon, Daniel T.
author_sort Viana, Mafalda
collection PubMed
description Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems.
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spelling pubmed-40075952014-05-05 Assembling evidence for identifying reservoirs of infection Viana, Mafalda Mancy, Rebecca Biek, Roman Cleaveland, Sarah Cross, Paul C. Lloyd-Smith, James O. Haydon, Daniel T. Trends Ecol Evol Article Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. The Authors. Published by Elsevier Ltd. 2014-05 2014-04-11 /pmc/articles/PMC4007595/ /pubmed/24726345 http://dx.doi.org/10.1016/j.tree.2014.03.002 Text en © 2014 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Viana, Mafalda
Mancy, Rebecca
Biek, Roman
Cleaveland, Sarah
Cross, Paul C.
Lloyd-Smith, James O.
Haydon, Daniel T.
Assembling evidence for identifying reservoirs of infection
title Assembling evidence for identifying reservoirs of infection
title_full Assembling evidence for identifying reservoirs of infection
title_fullStr Assembling evidence for identifying reservoirs of infection
title_full_unstemmed Assembling evidence for identifying reservoirs of infection
title_short Assembling evidence for identifying reservoirs of infection
title_sort assembling evidence for identifying reservoirs of infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007595/
https://www.ncbi.nlm.nih.gov/pubmed/24726345
http://dx.doi.org/10.1016/j.tree.2014.03.002
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