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Assembling evidence for identifying reservoirs of infection
Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007595/ https://www.ncbi.nlm.nih.gov/pubmed/24726345 http://dx.doi.org/10.1016/j.tree.2014.03.002 |
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author | Viana, Mafalda Mancy, Rebecca Biek, Roman Cleaveland, Sarah Cross, Paul C. Lloyd-Smith, James O. Haydon, Daniel T. |
author_facet | Viana, Mafalda Mancy, Rebecca Biek, Roman Cleaveland, Sarah Cross, Paul C. Lloyd-Smith, James O. Haydon, Daniel T. |
author_sort | Viana, Mafalda |
collection | PubMed |
description | Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. |
format | Online Article Text |
id | pubmed-4007595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Authors. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40075952014-05-05 Assembling evidence for identifying reservoirs of infection Viana, Mafalda Mancy, Rebecca Biek, Roman Cleaveland, Sarah Cross, Paul C. Lloyd-Smith, James O. Haydon, Daniel T. Trends Ecol Evol Article Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. The Authors. Published by Elsevier Ltd. 2014-05 2014-04-11 /pmc/articles/PMC4007595/ /pubmed/24726345 http://dx.doi.org/10.1016/j.tree.2014.03.002 Text en © 2014 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Viana, Mafalda Mancy, Rebecca Biek, Roman Cleaveland, Sarah Cross, Paul C. Lloyd-Smith, James O. Haydon, Daniel T. Assembling evidence for identifying reservoirs of infection |
title | Assembling evidence for identifying reservoirs of infection |
title_full | Assembling evidence for identifying reservoirs of infection |
title_fullStr | Assembling evidence for identifying reservoirs of infection |
title_full_unstemmed | Assembling evidence for identifying reservoirs of infection |
title_short | Assembling evidence for identifying reservoirs of infection |
title_sort | assembling evidence for identifying reservoirs of infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007595/ https://www.ncbi.nlm.nih.gov/pubmed/24726345 http://dx.doi.org/10.1016/j.tree.2014.03.002 |
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