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Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)
BACKGROUND: The ubiquitous non-receptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) plays a key role in RAS/ERK signaling downstream of most, if not all growth factors, cytokines and integrins, although its major substrates remain controversial. Mutations in PTPN11 lead to several distinct...
Autores principales: | Qiu, Wei, Wang, Xiaonan, Romanov, Vladimir, Hutchinson, Ashley, Lin, Andrés, Ruzanov, Maxim, Battaile, Kevin P, Pai, Emil F, Neel, Benjamin G, Chirgadze, Nickolay Y |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007598/ https://www.ncbi.nlm.nih.gov/pubmed/24628801 http://dx.doi.org/10.1186/1472-6807-14-10 |
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