Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity

DNA damage recognition subunits like DDB2 and XPC protect the human skin from ultraviolet (UV) light-induced genome instability and cancer, as demonstrated by the devastating inherited syndrome xeroderma pigmentosum. Here, we show that the beneficial DNA repair response triggered by these two genome...

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Detalles Bibliográficos
Autores principales: Puumalainen, Marjo-Riitta, Lessel, Davor, Rüthemann, Peter, Kaczmarek, Nina, Bachmann, Karin, Ramadan, Kristijan, Naegeli, Hanspeter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007632/
https://www.ncbi.nlm.nih.gov/pubmed/24770583
http://dx.doi.org/10.1038/ncomms4695

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