Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies

BACKGROUND: Short in-frame deletions in the second extracellular domain of the cytokine receptor gp130 are the leading cause of inflammatory hepatocellular adenomas (IHCAs). The deletions render gp130 constitutively active. In this study we investigate the intracellular signaling potential of one of...

Descripción completa

Detalles Bibliográficos
Autores principales: Rinis, Natalie, Küster, Andrea, Schmitz-Van de Leur, Hildegard, Mohr, Anne, Müller-Newen, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007646/
https://www.ncbi.nlm.nih.gov/pubmed/24612692
http://dx.doi.org/10.1186/1478-811X-12-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007646/
https://www.ncbi.nlm.nih.gov/pubmed/24612692
http://dx.doi.org/10.1186/1478-811X-12-14

Ejemplares similares