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Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies
BACKGROUND: Short in-frame deletions in the second extracellular domain of the cytokine receptor gp130 are the leading cause of inflammatory hepatocellular adenomas (IHCAs). The deletions render gp130 constitutively active. In this study we investigate the intracellular signaling potential of one of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007646/ https://www.ncbi.nlm.nih.gov/pubmed/24612692 http://dx.doi.org/10.1186/1478-811X-12-14 |