PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity

Tyrosine phosphorylation is implicated in regulating the adherens junction protein, p120 catenin (p120), however, the mechanisms are not well defined. Here, we show, using substrate trapping, that p120 is a direct target of the protein tyrosine phosphatase, PTP-PEST, in epithelial cells. Stable shRN...

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Detalles Bibliográficos
Autores principales: Espejo, Rosario, Jeng, Yowjiun, Paulucci-Holthauzen, Adriana, Rengifo-Cam, William, Honkus, Krysta, Anastasiadis, Panos Z., Sastry, Sarita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007762/
https://www.ncbi.nlm.nih.gov/pubmed/24284071
http://dx.doi.org/10.1242/jcs.120154

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