SILAC labeling coupled to shotgun proteomics analysis of membrane proteins of liver stem/hepatocyte allows to candidate the inhibition of TGF-beta pathway as causal to differentiation

BACKGROUND: Despite extensive research on hepatic cells precursors and their differentiated states, much remains to be learned about the mechanism underlying the self-renewal and differentiation. RESULTS: We apply the SILAC (stable isotope labeling by amino acids in cell culture) approach to quantit...

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Detalles Bibliográficos
Autores principales: Montaldo, Claudia, Mancone, Carmine, Conigliaro, Alice, Cozzolino, Angela Maria, de Nonno, Valeria, Tripodi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007997/
https://www.ncbi.nlm.nih.gov/pubmed/24628804
http://dx.doi.org/10.1186/1477-5956-12-15

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