Cargando…
Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes
Aims/Introduction: The aim of the present study was to evaluate the efficacy of replacing neutral protamine Hagedorn insulin (NPH) with the long‐acting insulin analogue, detemir, in clinical practice. Materials and Methods: We carried out a retrospective study to compare the effects of replacing N...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008018/ https://www.ncbi.nlm.nih.gov/pubmed/24843464 http://dx.doi.org/10.1111/j.2040-1124.2010.00066.x |
_version_ | 1782314388384907264 |
---|---|
author | Hayakawa, Taro Ishii, Michiyo Watanabe, Megumi Iwase, Hiroya Nishimura, Asako Monden, Takako Kamiuchi, Kenji Isono, Motohide Shibata, Nobuhito |
author_facet | Hayakawa, Taro Ishii, Michiyo Watanabe, Megumi Iwase, Hiroya Nishimura, Asako Monden, Takako Kamiuchi, Kenji Isono, Motohide Shibata, Nobuhito |
author_sort | Hayakawa, Taro |
collection | PubMed |
description | Aims/Introduction: The aim of the present study was to evaluate the efficacy of replacing neutral protamine Hagedorn insulin (NPH) with the long‐acting insulin analogue, detemir, in clinical practice. Materials and Methods: We carried out a retrospective study to compare the effects of replacing NPH with detemir in basal–bolus insulin therapy in Japanese patients with type 1 diabetes. A total of 19 patients were enrolled in the study, and changes in hemoglobin A(1c) (HbA(1c)), insulin dose, bodyweight, fasting blood glucose levels (FBG), within‐patient variability in FBG and prevalence in hypoglycemia were monitored for 12 weeks before replacement and during three periods after replacement; 1–12 weeks (period 1), 13–24 weeks (period 2) and 25–36 weeks (period 3). Results: HbA(1c) values improved significantly in periods 2 and 3. Despite the total insulin dose remaining unchanged throughout the study, the basal insulin dose increased from 0.24 to 0.27 IU/kg/day in period 2 and 0.28 IU/kg/day in period 3. Bodyweight decreased from 61.8 to 60.8 kg in period 1, whereas FBG improved throughout the study. Within‐patient variability in FBG was lower with detemir treatment than with NPH, despite the number of hypoglycemic episodes increasing significantly after replacement. Conclusions: These findings show that the weight loss observed in patients was independent of the reduction in calorie intake resulting from less frequent hypoglycemic attacks. In Japanese patients with diabetes who received NPH, replacing NPH with detemir led to improvements in glycemic control without any weight gain. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00066.x, 2010) |
format | Online Article Text |
id | pubmed-4008018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40080182014-05-19 Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes Hayakawa, Taro Ishii, Michiyo Watanabe, Megumi Iwase, Hiroya Nishimura, Asako Monden, Takako Kamiuchi, Kenji Isono, Motohide Shibata, Nobuhito J Diabetes Investig Articles Aims/Introduction: The aim of the present study was to evaluate the efficacy of replacing neutral protamine Hagedorn insulin (NPH) with the long‐acting insulin analogue, detemir, in clinical practice. Materials and Methods: We carried out a retrospective study to compare the effects of replacing NPH with detemir in basal–bolus insulin therapy in Japanese patients with type 1 diabetes. A total of 19 patients were enrolled in the study, and changes in hemoglobin A(1c) (HbA(1c)), insulin dose, bodyweight, fasting blood glucose levels (FBG), within‐patient variability in FBG and prevalence in hypoglycemia were monitored for 12 weeks before replacement and during three periods after replacement; 1–12 weeks (period 1), 13–24 weeks (period 2) and 25–36 weeks (period 3). Results: HbA(1c) values improved significantly in periods 2 and 3. Despite the total insulin dose remaining unchanged throughout the study, the basal insulin dose increased from 0.24 to 0.27 IU/kg/day in period 2 and 0.28 IU/kg/day in period 3. Bodyweight decreased from 61.8 to 60.8 kg in period 1, whereas FBG improved throughout the study. Within‐patient variability in FBG was lower with detemir treatment than with NPH, despite the number of hypoglycemic episodes increasing significantly after replacement. Conclusions: These findings show that the weight loss observed in patients was independent of the reduction in calorie intake resulting from less frequent hypoglycemic attacks. In Japanese patients with diabetes who received NPH, replacing NPH with detemir led to improvements in glycemic control without any weight gain. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00066.x, 2010) Blackwell Publishing Ltd 2011-01-24 2010-09-28 /pmc/articles/PMC4008018/ /pubmed/24843464 http://dx.doi.org/10.1111/j.2040-1124.2010.00066.x Text en © 2010 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd |
spellingShingle | Articles Hayakawa, Taro Ishii, Michiyo Watanabe, Megumi Iwase, Hiroya Nishimura, Asako Monden, Takako Kamiuchi, Kenji Isono, Motohide Shibata, Nobuhito Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes |
title | Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes |
title_full | Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes |
title_fullStr | Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes |
title_full_unstemmed | Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes |
title_short | Replacement of neutral protamine Hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in Japanese patients with type 1 diabetes |
title_sort | replacement of neutral protamine hagedorn insulin with the long‐acting insulin analogue, detemir, improves glycemic control without weight gain in basal–bolus insulin therapy in japanese patients with type 1 diabetes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008018/ https://www.ncbi.nlm.nih.gov/pubmed/24843464 http://dx.doi.org/10.1111/j.2040-1124.2010.00066.x |
work_keys_str_mv | AT hayakawataro replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT ishiimichiyo replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT watanabemegumi replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT iwasehiroya replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT nishimuraasako replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT mondentakako replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT kamiuchikenji replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT isonomotohide replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes AT shibatanobuhito replacementofneutralprotaminehagedorninsulinwiththelongactinginsulinanaloguedetemirimprovesglycemiccontrolwithoutweightgaininbasalbolusinsulintherapyinjapanesepatientswithtype1diabetes |