Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism

Spinal metastasis, a devastating neurologic complication of intracranial glioblastomas is not as uncommon as initially thought. It varies from 25% in supratentorial glioblastomas to 60% in infratentorial glioblastomas. The underlying pathogenesis spinal spread of high-grade gliomas is still unclear....

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Autores principales: Kaloshi, Gentian, Roji, Arben, Seferi, Arsen, Cakani, Bujar, Bushati, Teona, Roci, Ermir, Petrela, Mentor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AVICENA, d.o.o., Sarajevo 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008035/
https://www.ncbi.nlm.nih.gov/pubmed/24825943
http://dx.doi.org/10.5455/aim.2014.22.142-144
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author Kaloshi, Gentian
Roji, Arben
Seferi, Arsen
Cakani, Bujar
Bushati, Teona
Roci, Ermir
Petrela, Mentor
author_facet Kaloshi, Gentian
Roji, Arben
Seferi, Arsen
Cakani, Bujar
Bushati, Teona
Roci, Ermir
Petrela, Mentor
author_sort Kaloshi, Gentian
collection PubMed
description Spinal metastasis, a devastating neurologic complication of intracranial glioblastomas is not as uncommon as initially thought. It varies from 25% in supratentorial glioblastomas to 60% in infratentorial glioblastomas. The underlying pathogenesis spinal spread of high-grade gliomas is still unclear. To date, no causal responsibility of Bevacizumab (BEV) was noted. Here, we report for the first time, a case of thoracic intramedullary metastases from a cerebral glioblastoma pre-treated with BEV. A critical and exhaustive review is provided.
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spelling pubmed-40080352014-05-13 Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism Kaloshi, Gentian Roji, Arben Seferi, Arsen Cakani, Bujar Bushati, Teona Roci, Ermir Petrela, Mentor Acta Inform Med Case Report Spinal metastasis, a devastating neurologic complication of intracranial glioblastomas is not as uncommon as initially thought. It varies from 25% in supratentorial glioblastomas to 60% in infratentorial glioblastomas. The underlying pathogenesis spinal spread of high-grade gliomas is still unclear. To date, no causal responsibility of Bevacizumab (BEV) was noted. Here, we report for the first time, a case of thoracic intramedullary metastases from a cerebral glioblastoma pre-treated with BEV. A critical and exhaustive review is provided. AVICENA, d.o.o., Sarajevo 2014-03-17 2014-04 /pmc/articles/PMC4008035/ /pubmed/24825943 http://dx.doi.org/10.5455/aim.2014.22.142-144 Text en Copyright: © AVICENA http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kaloshi, Gentian
Roji, Arben
Seferi, Arsen
Cakani, Bujar
Bushati, Teona
Roci, Ermir
Petrela, Mentor
Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
title Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
title_full Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
title_fullStr Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
title_full_unstemmed Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
title_short Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism
title_sort spinal dissemination of intracranial glioblastoma in bevacizumab era: a potential bevacizumab-induced mechanism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008035/
https://www.ncbi.nlm.nih.gov/pubmed/24825943
http://dx.doi.org/10.5455/aim.2014.22.142-144
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