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Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients()
BACKGROUND: aAlthough rare, bullous pemphigoid (BP) is the most common autoimmune blistering disease. Recent studies have shown that patients with bullous pemphigoid are more likely to have neurological and psychiatric diseases, particularly prior to the diagnosis of bullous pemphigoid. OBJECTIVE: T...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008058/ https://www.ncbi.nlm.nih.gov/pubmed/24770504 http://dx.doi.org/10.1590/abd1806-4841.20142516 |
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author | Teixeira, Vera Barreto Cabral, Rita Brites, Maria Manuel Vieira, Ricardo Figueiredo, Américo |
author_facet | Teixeira, Vera Barreto Cabral, Rita Brites, Maria Manuel Vieira, Ricardo Figueiredo, Américo |
author_sort | Teixeira, Vera Barreto |
collection | PubMed |
description | BACKGROUND: aAlthough rare, bullous pemphigoid (BP) is the most common autoimmune blistering disease. Recent studies have shown that patients with bullous pemphigoid are more likely to have neurological and psychiatric diseases, particularly prior to the diagnosis of bullous pemphigoid. OBJECTIVE: The aims were: (i) to evaluate the demographic and clinical features of bullous pemphigoid from a database of patients at a Portuguese university hospital and (ii) to compare the prevalence of comorbid conditions before the diagnosis of bullous pemphigoid with a control group. METHODS: Seventy-seven patients with bullous pemphigoid were enrolled in the study. They were compared with 176 age- and gender-matched controls, which also had the same inpatient to outpatient ratio, but no history of bullous or cutaneous malignant disease. Univariate and multivariate analyses were used to calculate odds ratios for specific comorbid diseases. RESULTS: At least one neurologic diagnosis was present in 55.8% of BP patients compared with 20.5% controls (p<0.001). Comparing cases to controls, stroke was seen in 35.1 vs. 6.8%, OR 8.10 (3.80-17.25); dementia in 37.7 vs. 11.9%, OR 5.25 (2.71-10.16); and Parkinson's disease in 5.2 vs. 1.1%, OR 4.91 (0.88-27.44). Using multivariate analysis, all diseases except Parkinson's retained their association with BP. Patients under systemic treatment were eight times more likely to have complications than those treated with topical steroids (p< 0.017). CONCLUSIONS: The results of this study substantiate the association between BP and neurological diseases. In addition, they highlight the potential complications associated with the treatment of BP. |
format | Online Article Text |
id | pubmed-4008058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-40080582014-05-07 Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients() Teixeira, Vera Barreto Cabral, Rita Brites, Maria Manuel Vieira, Ricardo Figueiredo, Américo An Bras Dermatol Investigation BACKGROUND: aAlthough rare, bullous pemphigoid (BP) is the most common autoimmune blistering disease. Recent studies have shown that patients with bullous pemphigoid are more likely to have neurological and psychiatric diseases, particularly prior to the diagnosis of bullous pemphigoid. OBJECTIVE: The aims were: (i) to evaluate the demographic and clinical features of bullous pemphigoid from a database of patients at a Portuguese university hospital and (ii) to compare the prevalence of comorbid conditions before the diagnosis of bullous pemphigoid with a control group. METHODS: Seventy-seven patients with bullous pemphigoid were enrolled in the study. They were compared with 176 age- and gender-matched controls, which also had the same inpatient to outpatient ratio, but no history of bullous or cutaneous malignant disease. Univariate and multivariate analyses were used to calculate odds ratios for specific comorbid diseases. RESULTS: At least one neurologic diagnosis was present in 55.8% of BP patients compared with 20.5% controls (p<0.001). Comparing cases to controls, stroke was seen in 35.1 vs. 6.8%, OR 8.10 (3.80-17.25); dementia in 37.7 vs. 11.9%, OR 5.25 (2.71-10.16); and Parkinson's disease in 5.2 vs. 1.1%, OR 4.91 (0.88-27.44). Using multivariate analysis, all diseases except Parkinson's retained their association with BP. Patients under systemic treatment were eight times more likely to have complications than those treated with topical steroids (p< 0.017). CONCLUSIONS: The results of this study substantiate the association between BP and neurological diseases. In addition, they highlight the potential complications associated with the treatment of BP. Sociedade Brasileira de Dermatologia 2014 /pmc/articles/PMC4008058/ /pubmed/24770504 http://dx.doi.org/10.1590/abd1806-4841.20142516 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Investigation Teixeira, Vera Barreto Cabral, Rita Brites, Maria Manuel Vieira, Ricardo Figueiredo, Américo Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients() |
title | Bullous pemphigoid and comorbidities: a case-control study in Portuguese
patients()
|
title_full | Bullous pemphigoid and comorbidities: a case-control study in Portuguese
patients()
|
title_fullStr | Bullous pemphigoid and comorbidities: a case-control study in Portuguese
patients()
|
title_full_unstemmed | Bullous pemphigoid and comorbidities: a case-control study in Portuguese
patients()
|
title_short | Bullous pemphigoid and comorbidities: a case-control study in Portuguese
patients()
|
title_sort | bullous pemphigoid and comorbidities: a case-control study in portuguese
patients() |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008058/ https://www.ncbi.nlm.nih.gov/pubmed/24770504 http://dx.doi.org/10.1590/abd1806-4841.20142516 |
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