Cargando…
Biologic therapy for psoriasis - still searching for the best target()
Psoriasis is a chronic skin disease that results from the complex interaction between genetic and environmental factors. Over the last few decades, scientific evidence has redirected the focus of therapeutic studies to the immunologic pathways underlying its pathogenesis. This led to the biologic bo...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008081/ https://www.ncbi.nlm.nih.gov/pubmed/24770527 http://dx.doi.org/10.1590/abd1806-4841.20142898 |
_version_ | 1782314402902441984 |
---|---|
author | Pinto-Almeida, Teresa Torres, Tiago |
author_facet | Pinto-Almeida, Teresa Torres, Tiago |
author_sort | Pinto-Almeida, Teresa |
collection | PubMed |
description | Psoriasis is a chronic skin disease that results from the complex interaction between genetic and environmental factors. Over the last few decades, scientific evidence has redirected the focus of therapeutic studies to the immunologic pathways underlying its pathogenesis. This led to the biologic boom that we are currently experiencing, with the development and approval of targeted progressively more selective biological therapies and ongoing clinical trials of increasingly specific drugs, given their important implications for long-term efficacy and safety. Nevertheless, the search for the optimal biologic is still ongoing, and the best target has yet to be found. |
format | Online Article Text |
id | pubmed-4008081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-40080812014-05-07 Biologic therapy for psoriasis - still searching for the best target() Pinto-Almeida, Teresa Torres, Tiago An Bras Dermatol Communication Psoriasis is a chronic skin disease that results from the complex interaction between genetic and environmental factors. Over the last few decades, scientific evidence has redirected the focus of therapeutic studies to the immunologic pathways underlying its pathogenesis. This led to the biologic boom that we are currently experiencing, with the development and approval of targeted progressively more selective biological therapies and ongoing clinical trials of increasingly specific drugs, given their important implications for long-term efficacy and safety. Nevertheless, the search for the optimal biologic is still ongoing, and the best target has yet to be found. Sociedade Brasileira de Dermatologia 2014 /pmc/articles/PMC4008081/ /pubmed/24770527 http://dx.doi.org/10.1590/abd1806-4841.20142898 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Communication Pinto-Almeida, Teresa Torres, Tiago Biologic therapy for psoriasis - still searching for the best target() |
title | Biologic therapy for psoriasis - still searching for the best
target()
|
title_full | Biologic therapy for psoriasis - still searching for the best
target()
|
title_fullStr | Biologic therapy for psoriasis - still searching for the best
target()
|
title_full_unstemmed | Biologic therapy for psoriasis - still searching for the best
target()
|
title_short | Biologic therapy for psoriasis - still searching for the best
target()
|
title_sort | biologic therapy for psoriasis - still searching for the best
target() |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008081/ https://www.ncbi.nlm.nih.gov/pubmed/24770527 http://dx.doi.org/10.1590/abd1806-4841.20142898 |
work_keys_str_mv | AT pintoalmeidateresa biologictherapyforpsoriasisstillsearchingforthebesttarget AT torrestiago biologictherapyforpsoriasisstillsearchingforthebesttarget |