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Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression
Recent evidence indicates that the nature of interactions between the nervous system and immune system is important in the pathogenesis of depression. Specifically, alterations in pro-inflammatory cytokines have been related to the development of several psychological and neurobiological manifestati...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008288/ https://www.ncbi.nlm.nih.gov/pubmed/24851049 http://dx.doi.org/10.2147/NDT.S50197 |
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author | Bizik, Gustav Bob, Petr Raboch, Jiri Pavlat, Josef Uhrova, Jana Benakova, Hana Zima, Tomas |
author_facet | Bizik, Gustav Bob, Petr Raboch, Jiri Pavlat, Josef Uhrova, Jana Benakova, Hana Zima, Tomas |
author_sort | Bizik, Gustav |
collection | PubMed |
description | Recent evidence indicates that the nature of interactions between the nervous system and immune system is important in the pathogenesis of depression. Specifically, alterations in pro-inflammatory cytokines have been related to the development of several psychological and neurobiological manifestations of depressive disorder, as well as to stress exposure. A number of findings point to tumor necrosis factor alpha (TNF-α) as one of the central factors in these processes. Accordingly, in the present study, we test the hypothesis that specific influences of chronic stressors related to traumatic stress and dissociation are related to alterations in TNF-α levels. We performed psychometric measurement of depression (Beck Depression Inventory [BDI]-II), traumatic stress symptoms (Trauma Symptom Checklist [TSC]-40), and psychological and somatoform dissociation (Dissociative Experiences Scale [DES] and Somatoform Dissociation Questionnaire [SDQ]-20, respectively), and immunochemical measure of serum TNF-α in 66 inpatients with unipolar depression (mean age 43.1 ± 7.3 years). The results show that TNF-α is significantly related to DES (Spearman R=−0.42, P<0.01), SDQ-20 (Spearman R=−0.38, P<0.01), and TSC-40 (Spearman R=−0.41, P<0.01), but not to BDI-II. Results of the present study suggest that TNF-α levels are related to dissociative symptoms and stress exposure in depressed patients. |
format | Online Article Text |
id | pubmed-4008288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40082882014-05-21 Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression Bizik, Gustav Bob, Petr Raboch, Jiri Pavlat, Josef Uhrova, Jana Benakova, Hana Zima, Tomas Neuropsychiatr Dis Treat Short Report Recent evidence indicates that the nature of interactions between the nervous system and immune system is important in the pathogenesis of depression. Specifically, alterations in pro-inflammatory cytokines have been related to the development of several psychological and neurobiological manifestations of depressive disorder, as well as to stress exposure. A number of findings point to tumor necrosis factor alpha (TNF-α) as one of the central factors in these processes. Accordingly, in the present study, we test the hypothesis that specific influences of chronic stressors related to traumatic stress and dissociation are related to alterations in TNF-α levels. We performed psychometric measurement of depression (Beck Depression Inventory [BDI]-II), traumatic stress symptoms (Trauma Symptom Checklist [TSC]-40), and psychological and somatoform dissociation (Dissociative Experiences Scale [DES] and Somatoform Dissociation Questionnaire [SDQ]-20, respectively), and immunochemical measure of serum TNF-α in 66 inpatients with unipolar depression (mean age 43.1 ± 7.3 years). The results show that TNF-α is significantly related to DES (Spearman R=−0.42, P<0.01), SDQ-20 (Spearman R=−0.38, P<0.01), and TSC-40 (Spearman R=−0.41, P<0.01), but not to BDI-II. Results of the present study suggest that TNF-α levels are related to dissociative symptoms and stress exposure in depressed patients. Dove Medical Press 2014-04-25 /pmc/articles/PMC4008288/ /pubmed/24851049 http://dx.doi.org/10.2147/NDT.S50197 Text en © 2014 Bizik et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Short Report Bizik, Gustav Bob, Petr Raboch, Jiri Pavlat, Josef Uhrova, Jana Benakova, Hana Zima, Tomas Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
title | Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
title_full | Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
title_fullStr | Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
title_full_unstemmed | Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
title_short | Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
title_sort | dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008288/ https://www.ncbi.nlm.nih.gov/pubmed/24851049 http://dx.doi.org/10.2147/NDT.S50197 |
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