Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?

The percentage of circulating CD14(+)CD11b(+)HLA-DR(−/low) myeloid-derived suppressor cells (MDSCs) inversely correlates with survival among advanced melanoma patients. High levels of MDSCs are associated with the absence of T lymphocytes specific for melanoma-derived antigens, implying a causal and...

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Detalles Bibliográficos
Autores principales: Martens, Alexander, Zelba, Henning, Garbe, Claus, Pawelec, Graham, Weide, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008451/
https://www.ncbi.nlm.nih.gov/pubmed/24800171
http://dx.doi.org/10.4161/onci.27845
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author Martens, Alexander
Zelba, Henning
Garbe, Claus
Pawelec, Graham
Weide, Benjamin
author_facet Martens, Alexander
Zelba, Henning
Garbe, Claus
Pawelec, Graham
Weide, Benjamin
author_sort Martens, Alexander
collection PubMed
description The percentage of circulating CD14(+)CD11b(+)HLA-DR(−/low) myeloid-derived suppressor cells (MDSCs) inversely correlates with survival among advanced melanoma patients. High levels of MDSCs are associated with the absence of T lymphocytes specific for melanoma-derived antigens, implying a causal and clinically relevant interaction between these cell subsets. MDSCs might therefore represent prognostic markers as well as targets for the development of novel therapeutic interventions against melanoma.
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spelling pubmed-40084512015-02-14 Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses? Martens, Alexander Zelba, Henning Garbe, Claus Pawelec, Graham Weide, Benjamin Oncoimmunology Author's View The percentage of circulating CD14(+)CD11b(+)HLA-DR(−/low) myeloid-derived suppressor cells (MDSCs) inversely correlates with survival among advanced melanoma patients. High levels of MDSCs are associated with the absence of T lymphocytes specific for melanoma-derived antigens, implying a causal and clinically relevant interaction between these cell subsets. MDSCs might therefore represent prognostic markers as well as targets for the development of novel therapeutic interventions against melanoma. Landes Bioscience 2014-02-14 /pmc/articles/PMC4008451/ /pubmed/24800171 http://dx.doi.org/10.4161/onci.27845 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Martens, Alexander
Zelba, Henning
Garbe, Claus
Pawelec, Graham
Weide, Benjamin
Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
title Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
title_full Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
title_fullStr Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
title_full_unstemmed Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
title_short Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
title_sort monocytic myeloid-derived suppressor cells in advanced melanoma patients: indirect impact on prognosis through inhibition of tumor-specific t-cell responses?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008451/
https://www.ncbi.nlm.nih.gov/pubmed/24800171
http://dx.doi.org/10.4161/onci.27845
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