Is tumor (R)ejection by the immune system the “5th R” of radiobiology?

Traditional factors of DNA damage and tumor cell kill, described by the “4 R’s” of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a “5th R,” (immune-mediated) Rejection, which recognize...

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Detalles Bibliográficos
Autores principales: Golden, Encouse B, Formenti, Silvia C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008452/
https://www.ncbi.nlm.nih.gov/pubmed/24800177
http://dx.doi.org/10.4161/onci.28133
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author Golden, Encouse B
Formenti, Silvia C
author_facet Golden, Encouse B
Formenti, Silvia C
author_sort Golden, Encouse B
collection PubMed
description Traditional factors of DNA damage and tumor cell kill, described by the “4 R’s” of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a “5th R,” (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy.
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spelling pubmed-40084522015-03-07 Is tumor (R)ejection by the immune system the “5th R” of radiobiology? Golden, Encouse B Formenti, Silvia C Oncoimmunology Author's View Traditional factors of DNA damage and tumor cell kill, described by the “4 R’s” of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a “5th R,” (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy. Landes Bioscience 2014-03-07 /pmc/articles/PMC4008452/ /pubmed/24800177 http://dx.doi.org/10.4161/onci.28133 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Golden, Encouse B
Formenti, Silvia C
Is tumor (R)ejection by the immune system the “5th R” of radiobiology?
title Is tumor (R)ejection by the immune system the “5th R” of radiobiology?
title_full Is tumor (R)ejection by the immune system the “5th R” of radiobiology?
title_fullStr Is tumor (R)ejection by the immune system the “5th R” of radiobiology?
title_full_unstemmed Is tumor (R)ejection by the immune system the “5th R” of radiobiology?
title_short Is tumor (R)ejection by the immune system the “5th R” of radiobiology?
title_sort is tumor (r)ejection by the immune system the “5th r” of radiobiology?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008452/
https://www.ncbi.nlm.nih.gov/pubmed/24800177
http://dx.doi.org/10.4161/onci.28133
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