Application of iPS cell-derived macrophages to cancer therapy

We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intr...

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Autores principales: Senju, Satoru, Koba, Chihiro, Haruta, Miwa, Matsunaga, Yusuke, Matsumura, Keiko, Haga, Eriko, Sasaki, Yuko, Ikeda, Tokunori, Takamatsu, Koutaro, Nishimura, Yasuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008454/
https://www.ncbi.nlm.nih.gov/pubmed/24800175
http://dx.doi.org/10.4161/onci.27927
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author Senju, Satoru
Koba, Chihiro
Haruta, Miwa
Matsunaga, Yusuke
Matsumura, Keiko
Haga, Eriko
Sasaki, Yuko
Ikeda, Tokunori
Takamatsu, Koutaro
Nishimura, Yasuharu
author_facet Senju, Satoru
Koba, Chihiro
Haruta, Miwa
Matsunaga, Yusuke
Matsumura, Keiko
Haga, Eriko
Sasaki, Yuko
Ikeda, Tokunori
Takamatsu, Koutaro
Nishimura, Yasuharu
author_sort Senju, Satoru
collection PubMed
description We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection of iPS-MCs expressing interferon β significantly inhibited the growth of human gastric and pancreatic cancers implanted in the peritoneal cavity of immunocompromised mice.
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spelling pubmed-40084542015-02-14 Application of iPS cell-derived macrophages to cancer therapy Senju, Satoru Koba, Chihiro Haruta, Miwa Matsunaga, Yusuke Matsumura, Keiko Haga, Eriko Sasaki, Yuko Ikeda, Tokunori Takamatsu, Koutaro Nishimura, Yasuharu Oncoimmunology Author's View We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection of iPS-MCs expressing interferon β significantly inhibited the growth of human gastric and pancreatic cancers implanted in the peritoneal cavity of immunocompromised mice. Landes Bioscience 2014-02-14 /pmc/articles/PMC4008454/ /pubmed/24800175 http://dx.doi.org/10.4161/onci.27927 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Senju, Satoru
Koba, Chihiro
Haruta, Miwa
Matsunaga, Yusuke
Matsumura, Keiko
Haga, Eriko
Sasaki, Yuko
Ikeda, Tokunori
Takamatsu, Koutaro
Nishimura, Yasuharu
Application of iPS cell-derived macrophages to cancer therapy
title Application of iPS cell-derived macrophages to cancer therapy
title_full Application of iPS cell-derived macrophages to cancer therapy
title_fullStr Application of iPS cell-derived macrophages to cancer therapy
title_full_unstemmed Application of iPS cell-derived macrophages to cancer therapy
title_short Application of iPS cell-derived macrophages to cancer therapy
title_sort application of ips cell-derived macrophages to cancer therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008454/
https://www.ncbi.nlm.nih.gov/pubmed/24800175
http://dx.doi.org/10.4161/onci.27927
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