The Complex Interplay between ERK1/2, TGFβ/Smad, and Jagged/Notch Signaling Pathways in the Regulation of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Cells

Epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells is a major pathologic change in the development of proliferative vitreoretinopathy (PVR), which leads to severe visual impairment. ERK1/2 pathway has been reported to play a key role in the carcinogenesis, cancer metas...

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Detalles Bibliográficos
Autores principales: Chen, Xiaoyun, Xiao, Wei, Wang, Wencong, Luo, Lixia, Ye, Shaobi, Liu, Yizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008562/
https://www.ncbi.nlm.nih.gov/pubmed/24788939
http://dx.doi.org/10.1371/journal.pone.0096365

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