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Retinoic Acid and GM-CSF Coordinately Induce Retinal Dehydrogenase 2 (RALDH2) Expression through Cooperation between the RAR/RXR Complex and Sp1 in Dendritic Cells

Retinoic acid (RA)-producing dendritic cells (DCs) play critical roles in gut immunity. Retinal dehydrogenase 2 (RALDH2) encoded by Aldh1a2 is a key enzyme for generating RA in DCs. Granulocyte–macrophage colony-stimulating factor (GM-CSF) potently induces RALDH2 expression in DCs in an RA-dependent...

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Detalles Bibliográficos
Autores principales:	Ohoka, Yoshiharu, Yokota-Nakatsuma, Aya, Maeda, Naoko, Takeuchi, Hajime, Iwata, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008585/ https://www.ncbi.nlm.nih.gov/pubmed/24788806 http://dx.doi.org/10.1371/journal.pone.0096512

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