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High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design

A high-quality NMR solution structure is presented for protein hMcl-1(171–327) which comprises residues 171–327 of the human anti-apoptotic protein Mcl-1 (hMcl-1). Since this construct contains the three Bcl-2 homology (BH) sequence motifs which participate in forming a binding site for inhibitors o...

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Detalles Bibliográficos
Autores principales:	Liu, Gaohua, Poppe, Leszek, Aoki, Ken, Yamane, Harvey, Lewis, Jeffrey, Szyperski, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008586/ https://www.ncbi.nlm.nih.gov/pubmed/24789074 http://dx.doi.org/10.1371/journal.pone.0096521

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