A case of tinnitus induced by chlorpromazine in a pediatric patient

Chlorpromazine is a well-known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred...

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Autores principales: Carnovale, Carla, Pellegrino, Paolo, Beretta, Silvia, Zuccotti, Gian Vincenzo, Perrone, Valentina, Antoniazzi, Stefania, Pozzi, Marco, Clementi, Emilio, Radice, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008917/
https://www.ncbi.nlm.nih.gov/pubmed/24799822
http://dx.doi.org/10.4103/0976-500X.130110
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author Carnovale, Carla
Pellegrino, Paolo
Beretta, Silvia
Zuccotti, Gian Vincenzo
Perrone, Valentina
Antoniazzi, Stefania
Pozzi, Marco
Clementi, Emilio
Radice, Sonia
author_facet Carnovale, Carla
Pellegrino, Paolo
Beretta, Silvia
Zuccotti, Gian Vincenzo
Perrone, Valentina
Antoniazzi, Stefania
Pozzi, Marco
Clementi, Emilio
Radice, Sonia
author_sort Carnovale, Carla
collection PubMed
description Chlorpromazine is a well-known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12-year-old boy, affected by severe generalized anxiety disorder. After treatment with chlorpromazine, the patient experienced an enhanced sensitivity to sounds accompanied by perception of noises of the buzzing or ringing type. This clinical case is of great clinical interest as chlorpromazine is not currently included among potentially ototoxic drugs.
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spelling pubmed-40089172014-05-05 A case of tinnitus induced by chlorpromazine in a pediatric patient Carnovale, Carla Pellegrino, Paolo Beretta, Silvia Zuccotti, Gian Vincenzo Perrone, Valentina Antoniazzi, Stefania Pozzi, Marco Clementi, Emilio Radice, Sonia J Pharmacol Pharmacother Case Report Chlorpromazine is a well-known antipsychotic agent that binds with a variety of receptors in the central nervous system. To date, chlorpromazine has never been associated with onset of hearing disorders and tinnitus. We report on an unexpected suspect adverse reaction to chlorpromazine that occurred in a 12-year-old boy, affected by severe generalized anxiety disorder. After treatment with chlorpromazine, the patient experienced an enhanced sensitivity to sounds accompanied by perception of noises of the buzzing or ringing type. This clinical case is of great clinical interest as chlorpromazine is not currently included among potentially ototoxic drugs. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4008917/ /pubmed/24799822 http://dx.doi.org/10.4103/0976-500X.130110 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Carnovale, Carla
Pellegrino, Paolo
Beretta, Silvia
Zuccotti, Gian Vincenzo
Perrone, Valentina
Antoniazzi, Stefania
Pozzi, Marco
Clementi, Emilio
Radice, Sonia
A case of tinnitus induced by chlorpromazine in a pediatric patient
title A case of tinnitus induced by chlorpromazine in a pediatric patient
title_full A case of tinnitus induced by chlorpromazine in a pediatric patient
title_fullStr A case of tinnitus induced by chlorpromazine in a pediatric patient
title_full_unstemmed A case of tinnitus induced by chlorpromazine in a pediatric patient
title_short A case of tinnitus induced by chlorpromazine in a pediatric patient
title_sort case of tinnitus induced by chlorpromazine in a pediatric patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008917/
https://www.ncbi.nlm.nih.gov/pubmed/24799822
http://dx.doi.org/10.4103/0976-500X.130110
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