Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway

The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as we...

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Detalles Bibliográficos
Autores principales: Li, Chenghua, Xiao, Zhi-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009111/
https://www.ncbi.nlm.nih.gov/pubmed/24822180
http://dx.doi.org/10.1155/2014/175721
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author Li, Chenghua
Xiao, Zhi-Xiong
author_facet Li, Chenghua
Xiao, Zhi-Xiong
author_sort Li, Chenghua
collection PubMed
description The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds of proteins are involved in regulation of p63 protein stability. These regulators are responsive to diverse extracellular signaling, resulting in changes of the p63 protein levels and impacting different biological processes.
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spelling pubmed-40091112014-05-12 Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway Li, Chenghua Xiao, Zhi-Xiong Biomed Res Int Review Article The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds of proteins are involved in regulation of p63 protein stability. These regulators are responsive to diverse extracellular signaling, resulting in changes of the p63 protein levels and impacting different biological processes. Hindawi Publishing Corporation 2014 2014-04-15 /pmc/articles/PMC4009111/ /pubmed/24822180 http://dx.doi.org/10.1155/2014/175721 Text en Copyright © 2014 C. Li and Z.-X. Xiao. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Chenghua
Xiao, Zhi-Xiong
Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway
title Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway
title_full Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway
title_fullStr Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway
title_full_unstemmed Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway
title_short Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway
title_sort regulation of p63 protein stability via ubiquitin-proteasome pathway
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009111/
https://www.ncbi.nlm.nih.gov/pubmed/24822180
http://dx.doi.org/10.1155/2014/175721
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AT xiaozhixiong regulationofp63proteinstabilityviaubiquitinproteasomepathway

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