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Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder

Conduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity...

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Autores principales: Zhang, Jibiao, Gao, Junling, Shi, Huqing, Huang, Bingsheng, Wang, Xiang, Situ, Weijun, Cai, Weixiong, Yi, Jinyao, Zhu, Xiongzhao, Yao, Shuqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009134/
https://www.ncbi.nlm.nih.gov/pubmed/24829912
http://dx.doi.org/10.1155/2014/673165
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author Zhang, Jibiao
Gao, Junling
Shi, Huqing
Huang, Bingsheng
Wang, Xiang
Situ, Weijun
Cai, Weixiong
Yi, Jinyao
Zhu, Xiongzhao
Yao, Shuqiao
author_facet Zhang, Jibiao
Gao, Junling
Shi, Huqing
Huang, Bingsheng
Wang, Xiang
Situ, Weijun
Cai, Weixiong
Yi, Jinyao
Zhu, Xiongzhao
Yao, Shuqiao
author_sort Zhang, Jibiao
collection PubMed
description Conduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls.
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spelling pubmed-40091342014-05-14 Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder Zhang, Jibiao Gao, Junling Shi, Huqing Huang, Bingsheng Wang, Xiang Situ, Weijun Cai, Weixiong Yi, Jinyao Zhu, Xiongzhao Yao, Shuqiao Biomed Res Int Research Article Conduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls. Hindawi Publishing Corporation 2014 2014-04-14 /pmc/articles/PMC4009134/ /pubmed/24829912 http://dx.doi.org/10.1155/2014/673165 Text en Copyright © 2014 Jibiao Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Jibiao
Gao, Junling
Shi, Huqing
Huang, Bingsheng
Wang, Xiang
Situ, Weijun
Cai, Weixiong
Yi, Jinyao
Zhu, Xiongzhao
Yao, Shuqiao
Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder
title Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder
title_full Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder
title_fullStr Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder
title_full_unstemmed Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder
title_short Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder
title_sort sex differences of uncinate fasciculus structural connectivity in individuals with conduct disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009134/
https://www.ncbi.nlm.nih.gov/pubmed/24829912
http://dx.doi.org/10.1155/2014/673165
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