Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report

Gastric cancer is one of most common types of cancers. Metastatic gastric cancer has a poor prognosis and is accepted as incurable at this stage. Treatment of metastatic gastric cancer did not progress substantially until new targeted agents have come out. Recently published ToGA trial showed promis...

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Autores principales: Suner, Ali, Buyukhatipoglu, Hakan, Balakan, Ozan, Kalender, Mehmet Emin, Ulas, Turgay, Sevinc, Alper, Camci, Celalettin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009157/
https://www.ncbi.nlm.nih.gov/pubmed/24822142
http://dx.doi.org/10.1155/2014/731581
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author Suner, Ali
Buyukhatipoglu, Hakan
Balakan, Ozan
Kalender, Mehmet Emin
Ulas, Turgay
Sevinc, Alper
Camci, Celalettin
author_facet Suner, Ali
Buyukhatipoglu, Hakan
Balakan, Ozan
Kalender, Mehmet Emin
Ulas, Turgay
Sevinc, Alper
Camci, Celalettin
author_sort Suner, Ali
collection PubMed
description Gastric cancer is one of most common types of cancers. Metastatic gastric cancer has a poor prognosis and is accepted as incurable at this stage. Treatment of metastatic gastric cancer did not progress substantially until new targeted agents have come out. Recently published ToGA trial showed promising results in HER2 overexpressing metastatic gastric cancer. In this case we present a case with an excellent complete response with anti-HER2 treatment. Most importantly, we wanted to emphasize (1) the importance of early determination of HER2 overexpression, and (2) to draw attention of anti-HER2 agents in the first line treatment even in patients with a poor performance status.
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spelling pubmed-40091572014-05-12 Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report Suner, Ali Buyukhatipoglu, Hakan Balakan, Ozan Kalender, Mehmet Emin Ulas, Turgay Sevinc, Alper Camci, Celalettin Case Rep Oncol Med Case Report Gastric cancer is one of most common types of cancers. Metastatic gastric cancer has a poor prognosis and is accepted as incurable at this stage. Treatment of metastatic gastric cancer did not progress substantially until new targeted agents have come out. Recently published ToGA trial showed promising results in HER2 overexpressing metastatic gastric cancer. In this case we present a case with an excellent complete response with anti-HER2 treatment. Most importantly, we wanted to emphasize (1) the importance of early determination of HER2 overexpression, and (2) to draw attention of anti-HER2 agents in the first line treatment even in patients with a poor performance status. Hindawi Publishing Corporation 2014 2014-04-13 /pmc/articles/PMC4009157/ /pubmed/24822142 http://dx.doi.org/10.1155/2014/731581 Text en Copyright © 2014 Ali Suner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Suner, Ali
Buyukhatipoglu, Hakan
Balakan, Ozan
Kalender, Mehmet Emin
Ulas, Turgay
Sevinc, Alper
Camci, Celalettin
Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report
title Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report
title_full Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report
title_fullStr Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report
title_full_unstemmed Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report
title_short Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report
title_sort importance of her2 work-up and treatment even in patients with poor performance status: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009157/
https://www.ncbi.nlm.nih.gov/pubmed/24822142
http://dx.doi.org/10.1155/2014/731581
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