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Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis

Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen...

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Detalles Bibliográficos
Autores principales: Xie, Keliang, Liu, Lingling, Yu, Yonghao, Wang, Guolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009185/
https://www.ncbi.nlm.nih.gov/pubmed/24829918
http://dx.doi.org/10.1155/2014/807635
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author Xie, Keliang
Liu, Lingling
Yu, Yonghao
Wang, Guolin
author_facet Xie, Keliang
Liu, Lingling
Yu, Yonghao
Wang, Guolin
author_sort Xie, Keliang
collection PubMed
description Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF-κB and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.
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spelling pubmed-40091852014-05-14 Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis Xie, Keliang Liu, Lingling Yu, Yonghao Wang, Guolin Biomed Res Int Review Article Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF-κB and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis. Hindawi Publishing Corporation 2014 2014-04-16 /pmc/articles/PMC4009185/ /pubmed/24829918 http://dx.doi.org/10.1155/2014/807635 Text en Copyright © 2014 Keliang Xie et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xie, Keliang
Liu, Lingling
Yu, Yonghao
Wang, Guolin
Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
title Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
title_full Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
title_fullStr Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
title_full_unstemmed Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
title_short Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
title_sort hydrogen gas presents a promising therapeutic strategy for sepsis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009185/
https://www.ncbi.nlm.nih.gov/pubmed/24829918
http://dx.doi.org/10.1155/2014/807635
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