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Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009185/ https://www.ncbi.nlm.nih.gov/pubmed/24829918 http://dx.doi.org/10.1155/2014/807635 |
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author | Xie, Keliang Liu, Lingling Yu, Yonghao Wang, Guolin |
author_facet | Xie, Keliang Liu, Lingling Yu, Yonghao Wang, Guolin |
author_sort | Xie, Keliang |
collection | PubMed |
description | Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF-κB and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis. |
format | Online Article Text |
id | pubmed-4009185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40091852014-05-14 Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis Xie, Keliang Liu, Lingling Yu, Yonghao Wang, Guolin Biomed Res Int Review Article Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF-κB and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis. Hindawi Publishing Corporation 2014 2014-04-16 /pmc/articles/PMC4009185/ /pubmed/24829918 http://dx.doi.org/10.1155/2014/807635 Text en Copyright © 2014 Keliang Xie et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xie, Keliang Liu, Lingling Yu, Yonghao Wang, Guolin Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis |
title | Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis |
title_full | Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis |
title_fullStr | Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis |
title_full_unstemmed | Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis |
title_short | Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis |
title_sort | hydrogen gas presents a promising therapeutic strategy for sepsis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009185/ https://www.ncbi.nlm.nih.gov/pubmed/24829918 http://dx.doi.org/10.1155/2014/807635 |
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