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Animal Models of Subjective Tinnitus
Tinnitus is one of the major audiological diseases, affecting a significant portion of the ageing society. Despite its huge personal and presumed economic impact there are only limited therapeutic options available. The reason for this deficiency lies in the very nature of the disease as it is deepl...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009209/ https://www.ncbi.nlm.nih.gov/pubmed/24829805 http://dx.doi.org/10.1155/2014/741452 |
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author | von der Behrens, Wolfger |
author_facet | von der Behrens, Wolfger |
author_sort | von der Behrens, Wolfger |
collection | PubMed |
description | Tinnitus is one of the major audiological diseases, affecting a significant portion of the ageing society. Despite its huge personal and presumed economic impact there are only limited therapeutic options available. The reason for this deficiency lies in the very nature of the disease as it is deeply connected to elementary plasticity of auditory processing in the central nervous system. Understanding these mechanisms is essential for developing a therapy that reverses the plastic changes underlying the pathogenesis of tinnitus. This requires experiments that address individual neurons and small networks, something usually not feasible in human patients. However, in animals such invasive experiments on the level of single neurons with high spatial and temporal resolution are possible. Therefore, animal models are a very critical element in the combined efforts for engineering new therapies. This review provides an overview over the most important features of animal models of tinnitus: which laboratory species are suitable, how to induce tinnitus, and how to characterize the perceived tinnitus by behavioral means. In particular, these aspects of tinnitus animal models are discussed in the light of transferability to the human patients. |
format | Online Article Text |
id | pubmed-4009209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40092092014-05-14 Animal Models of Subjective Tinnitus von der Behrens, Wolfger Neural Plast Review Article Tinnitus is one of the major audiological diseases, affecting a significant portion of the ageing society. Despite its huge personal and presumed economic impact there are only limited therapeutic options available. The reason for this deficiency lies in the very nature of the disease as it is deeply connected to elementary plasticity of auditory processing in the central nervous system. Understanding these mechanisms is essential for developing a therapy that reverses the plastic changes underlying the pathogenesis of tinnitus. This requires experiments that address individual neurons and small networks, something usually not feasible in human patients. However, in animals such invasive experiments on the level of single neurons with high spatial and temporal resolution are possible. Therefore, animal models are a very critical element in the combined efforts for engineering new therapies. This review provides an overview over the most important features of animal models of tinnitus: which laboratory species are suitable, how to induce tinnitus, and how to characterize the perceived tinnitus by behavioral means. In particular, these aspects of tinnitus animal models are discussed in the light of transferability to the human patients. Hindawi Publishing Corporation 2014 2014-04-16 /pmc/articles/PMC4009209/ /pubmed/24829805 http://dx.doi.org/10.1155/2014/741452 Text en Copyright © 2014 Wolfger von der Behrens. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article von der Behrens, Wolfger Animal Models of Subjective Tinnitus |
title | Animal Models of Subjective Tinnitus |
title_full | Animal Models of Subjective Tinnitus |
title_fullStr | Animal Models of Subjective Tinnitus |
title_full_unstemmed | Animal Models of Subjective Tinnitus |
title_short | Animal Models of Subjective Tinnitus |
title_sort | animal models of subjective tinnitus |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009209/ https://www.ncbi.nlm.nih.gov/pubmed/24829805 http://dx.doi.org/10.1155/2014/741452 |
work_keys_str_mv | AT vonderbehrenswolfger animalmodelsofsubjectivetinnitus |