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Plastic Changes in the Spinal Cord in Motor Neuron Disease

In the present paper, we analyze the cell number within lamina X at the end stage of disease in a G93A mouse model of ALS; the effects induced by lithium; the stem-cell like phenotype of lamina X cells during ALS; the differentiation of these cells towards either a glial or neuronal phenotype. In su...

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Autores principales: Fornai, Francesco, Ferrucci, Michela, Lenzi, Paola, Falleni, Alessandra, Biagioni, Francesca, Flaibani, Marina, Siciliano, Gabriele, Giannessi, Francesco, Paparelli, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009217/
https://www.ncbi.nlm.nih.gov/pubmed/24829911
http://dx.doi.org/10.1155/2014/670756
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author Fornai, Francesco
Ferrucci, Michela
Lenzi, Paola
Falleni, Alessandra
Biagioni, Francesca
Flaibani, Marina
Siciliano, Gabriele
Giannessi, Francesco
Paparelli, Antonio
author_facet Fornai, Francesco
Ferrucci, Michela
Lenzi, Paola
Falleni, Alessandra
Biagioni, Francesca
Flaibani, Marina
Siciliano, Gabriele
Giannessi, Francesco
Paparelli, Antonio
author_sort Fornai, Francesco
collection PubMed
description In the present paper, we analyze the cell number within lamina X at the end stage of disease in a G93A mouse model of ALS; the effects induced by lithium; the stem-cell like phenotype of lamina X cells during ALS; the differentiation of these cells towards either a glial or neuronal phenotype. In summary we found that G93A mouse model of ALS produces an increase in lamina X cells which is further augmented by lithium administration. In the absence of lithium these nestin positive stem-like cells preferentially differentiate into glia (GFAP positive), while in the presence of lithium these cells differentiate towards a neuron-like phenotype (βIII-tubulin, NeuN, and calbindin-D28K positive). These effects of lithium are observed concomitantly with attenuation in disease progression and are reminiscent of neurogenetic effects induced by lithium in the subependymal ventricular zone of the hippocampus.
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spelling pubmed-40092172014-05-14 Plastic Changes in the Spinal Cord in Motor Neuron Disease Fornai, Francesco Ferrucci, Michela Lenzi, Paola Falleni, Alessandra Biagioni, Francesca Flaibani, Marina Siciliano, Gabriele Giannessi, Francesco Paparelli, Antonio Biomed Res Int Research Article In the present paper, we analyze the cell number within lamina X at the end stage of disease in a G93A mouse model of ALS; the effects induced by lithium; the stem-cell like phenotype of lamina X cells during ALS; the differentiation of these cells towards either a glial or neuronal phenotype. In summary we found that G93A mouse model of ALS produces an increase in lamina X cells which is further augmented by lithium administration. In the absence of lithium these nestin positive stem-like cells preferentially differentiate into glia (GFAP positive), while in the presence of lithium these cells differentiate towards a neuron-like phenotype (βIII-tubulin, NeuN, and calbindin-D28K positive). These effects of lithium are observed concomitantly with attenuation in disease progression and are reminiscent of neurogenetic effects induced by lithium in the subependymal ventricular zone of the hippocampus. Hindawi Publishing Corporation 2014 2014-04-16 /pmc/articles/PMC4009217/ /pubmed/24829911 http://dx.doi.org/10.1155/2014/670756 Text en Copyright © 2014 Francesco Fornai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fornai, Francesco
Ferrucci, Michela
Lenzi, Paola
Falleni, Alessandra
Biagioni, Francesca
Flaibani, Marina
Siciliano, Gabriele
Giannessi, Francesco
Paparelli, Antonio
Plastic Changes in the Spinal Cord in Motor Neuron Disease
title Plastic Changes in the Spinal Cord in Motor Neuron Disease
title_full Plastic Changes in the Spinal Cord in Motor Neuron Disease
title_fullStr Plastic Changes in the Spinal Cord in Motor Neuron Disease
title_full_unstemmed Plastic Changes in the Spinal Cord in Motor Neuron Disease
title_short Plastic Changes in the Spinal Cord in Motor Neuron Disease
title_sort plastic changes in the spinal cord in motor neuron disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009217/
https://www.ncbi.nlm.nih.gov/pubmed/24829911
http://dx.doi.org/10.1155/2014/670756
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