A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis

A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positiv...

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Autores principales: Saito, Eiko, Sato, Shinji, Nogi, Shinichi, Sasaki, Noriko, Chinen, Naofumi, Honda, Kiri, Wakabayashi, Takayuki, Yamada, Chiho, Nakamura, Naoya, Suzuki, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009268/
https://www.ncbi.nlm.nih.gov/pubmed/24839573
http://dx.doi.org/10.1155/2014/386328
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author Saito, Eiko
Sato, Shinji
Nogi, Shinichi
Sasaki, Noriko
Chinen, Naofumi
Honda, Kiri
Wakabayashi, Takayuki
Yamada, Chiho
Nakamura, Naoya
Suzuki, Yasuo
author_facet Saito, Eiko
Sato, Shinji
Nogi, Shinichi
Sasaki, Noriko
Chinen, Naofumi
Honda, Kiri
Wakabayashi, Takayuki
Yamada, Chiho
Nakamura, Naoya
Suzuki, Yasuo
author_sort Saito, Eiko
collection PubMed
description A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. Because of gradually worsening arthritis, tocilizumab was administered and arthritis improved markedly. Interestingly, lymphadenopathy and PBC improved simultaneously. This suggested that interleukin-6 might play an important role in reactive lymphadenopathy and PBC associated with RA/lSSc.
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spelling pubmed-40092682014-05-18 A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis Saito, Eiko Sato, Shinji Nogi, Shinichi Sasaki, Noriko Chinen, Naofumi Honda, Kiri Wakabayashi, Takayuki Yamada, Chiho Nakamura, Naoya Suzuki, Yasuo Case Rep Rheumatol Case Report A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. Because of gradually worsening arthritis, tocilizumab was administered and arthritis improved markedly. Interestingly, lymphadenopathy and PBC improved simultaneously. This suggested that interleukin-6 might play an important role in reactive lymphadenopathy and PBC associated with RA/lSSc. Hindawi Publishing Corporation 2014 2014-04-15 /pmc/articles/PMC4009268/ /pubmed/24839573 http://dx.doi.org/10.1155/2014/386328 Text en Copyright © 2014 Eiko Saito et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Saito, Eiko
Sato, Shinji
Nogi, Shinichi
Sasaki, Noriko
Chinen, Naofumi
Honda, Kiri
Wakabayashi, Takayuki
Yamada, Chiho
Nakamura, Naoya
Suzuki, Yasuo
A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
title A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
title_full A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
title_fullStr A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
title_full_unstemmed A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
title_short A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
title_sort case of rheumatoid arthritis and limited systemic sclerosis overlap successfully treated with tocilizumab for arthritis and concomitant generalized lymphadenopathy and primary biliary cirrhosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009268/
https://www.ncbi.nlm.nih.gov/pubmed/24839573
http://dx.doi.org/10.1155/2014/386328
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