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Stem Cell Niches in Glioblastoma: A Neuropathological View

Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target, if they had no molecular mechanisms of resistance, in comparison with the mass of more differentiated cells which are insensitive to therapies just...

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Autores principales: Schiffer, Davide, Mellai, Marta, Annovazzi, Laura, Caldera, Valentina, Piazzi, Angela, Denysenko, Tetyana, Melcarne, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009309/
https://www.ncbi.nlm.nih.gov/pubmed/24834433
http://dx.doi.org/10.1155/2014/725921
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author Schiffer, Davide
Mellai, Marta
Annovazzi, Laura
Caldera, Valentina
Piazzi, Angela
Denysenko, Tetyana
Melcarne, Antonio
author_facet Schiffer, Davide
Mellai, Marta
Annovazzi, Laura
Caldera, Valentina
Piazzi, Angela
Denysenko, Tetyana
Melcarne, Antonio
author_sort Schiffer, Davide
collection PubMed
description Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target, if they had no molecular mechanisms of resistance, in comparison with the mass of more differentiated cells which are insensitive to therapies just because of being differentiated and nonproliferating. GSCs occur in tumor niches where both stemness status and angiogenesis are conditioned by the microenvironment. In both perivascular and perinecrotic niches, hypoxia plays a fundamental role. Fifteen glioblastomas have been studied by immunohistochemistry and immunofluorescence for stemness and differentiation antigens. It has been found that circumscribed necroses develop inside hyperproliferating areas that are characterized by high expression of stemness antigens. Necrosis developed inside them because of the imbalance between the proliferation of tumor cells and endothelial cells; it reduces the number of GSCs to a thin ring around the former hyperproliferating area. The perinecrotic GSCs are nothing else that the survivors remnants of those populating hyperproliferating areas. In the tumor, GSCs coincide with malignant areas so that the need to detect where they are located is not so urgent.
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spelling pubmed-40093092014-05-15 Stem Cell Niches in Glioblastoma: A Neuropathological View Schiffer, Davide Mellai, Marta Annovazzi, Laura Caldera, Valentina Piazzi, Angela Denysenko, Tetyana Melcarne, Antonio Biomed Res Int Research Article Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target, if they had no molecular mechanisms of resistance, in comparison with the mass of more differentiated cells which are insensitive to therapies just because of being differentiated and nonproliferating. GSCs occur in tumor niches where both stemness status and angiogenesis are conditioned by the microenvironment. In both perivascular and perinecrotic niches, hypoxia plays a fundamental role. Fifteen glioblastomas have been studied by immunohistochemistry and immunofluorescence for stemness and differentiation antigens. It has been found that circumscribed necroses develop inside hyperproliferating areas that are characterized by high expression of stemness antigens. Necrosis developed inside them because of the imbalance between the proliferation of tumor cells and endothelial cells; it reduces the number of GSCs to a thin ring around the former hyperproliferating area. The perinecrotic GSCs are nothing else that the survivors remnants of those populating hyperproliferating areas. In the tumor, GSCs coincide with malignant areas so that the need to detect where they are located is not so urgent. Hindawi Publishing Corporation 2014 2014-04-15 /pmc/articles/PMC4009309/ /pubmed/24834433 http://dx.doi.org/10.1155/2014/725921 Text en Copyright © 2014 Davide Schiffer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Schiffer, Davide
Mellai, Marta
Annovazzi, Laura
Caldera, Valentina
Piazzi, Angela
Denysenko, Tetyana
Melcarne, Antonio
Stem Cell Niches in Glioblastoma: A Neuropathological View
title Stem Cell Niches in Glioblastoma: A Neuropathological View
title_full Stem Cell Niches in Glioblastoma: A Neuropathological View
title_fullStr Stem Cell Niches in Glioblastoma: A Neuropathological View
title_full_unstemmed Stem Cell Niches in Glioblastoma: A Neuropathological View
title_short Stem Cell Niches in Glioblastoma: A Neuropathological View
title_sort stem cell niches in glioblastoma: a neuropathological view
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009309/
https://www.ncbi.nlm.nih.gov/pubmed/24834433
http://dx.doi.org/10.1155/2014/725921
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