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Transient dynamic mechanical properties of resilin-based elastomeric hydrogels

The outstanding high-frequency properties of emerging resilin-like polypeptides (RLPs) have motivated their development for vocal fold tissue regeneration and other applications. Recombinant RLP hydrogels show efficient gelation, tunable mechanical properties, and display excellent extensibility, bu...

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Detalles Bibliográficos
Autores principales: Li, Linqing, Kiick, Kristi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009447/
https://www.ncbi.nlm.nih.gov/pubmed/24809044
http://dx.doi.org/10.3389/fchem.2014.00021
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author Li, Linqing
Kiick, Kristi L.
author_facet Li, Linqing
Kiick, Kristi L.
author_sort Li, Linqing
collection PubMed
description The outstanding high-frequency properties of emerging resilin-like polypeptides (RLPs) have motivated their development for vocal fold tissue regeneration and other applications. Recombinant RLP hydrogels show efficient gelation, tunable mechanical properties, and display excellent extensibility, but little has been reported about their transient mechanical properties. In this manuscript, we describe the transient mechanical behavior of new RLP hydrogels investigated via both sinusoidal oscillatory shear deformation and uniaxial tensile testing. Oscillatory stress relaxation and creep experiments confirm that RLP-based hydrogels display significantly reduced stress relaxation and improved strain recovery compared to PEG-based control hydrogels. Uniaxial tensile testing confirms the negligible hysteresis, reversible elasticity and superior resilience (up to 98%) of hydrated RLP hydrogels, with Young's modulus values that compare favorably with those previously reported for resilin and that mimic the tensile properties of the vocal fold ligament at low strain (<15%). These studies expand our understanding of the properties of these RLP materials under a variety of conditions, and confirm the unique applicability, for mechanically demanding tissue engineering applications, of a range of RLP hydrogels.
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spelling pubmed-40094472014-05-07 Transient dynamic mechanical properties of resilin-based elastomeric hydrogels Li, Linqing Kiick, Kristi L. Front Chem Chemistry The outstanding high-frequency properties of emerging resilin-like polypeptides (RLPs) have motivated their development for vocal fold tissue regeneration and other applications. Recombinant RLP hydrogels show efficient gelation, tunable mechanical properties, and display excellent extensibility, but little has been reported about their transient mechanical properties. In this manuscript, we describe the transient mechanical behavior of new RLP hydrogels investigated via both sinusoidal oscillatory shear deformation and uniaxial tensile testing. Oscillatory stress relaxation and creep experiments confirm that RLP-based hydrogels display significantly reduced stress relaxation and improved strain recovery compared to PEG-based control hydrogels. Uniaxial tensile testing confirms the negligible hysteresis, reversible elasticity and superior resilience (up to 98%) of hydrated RLP hydrogels, with Young's modulus values that compare favorably with those previously reported for resilin and that mimic the tensile properties of the vocal fold ligament at low strain (<15%). These studies expand our understanding of the properties of these RLP materials under a variety of conditions, and confirm the unique applicability, for mechanically demanding tissue engineering applications, of a range of RLP hydrogels. Frontiers Media S.A. 2014-04-28 /pmc/articles/PMC4009447/ /pubmed/24809044 http://dx.doi.org/10.3389/fchem.2014.00021 Text en Copyright © 2014 Li and Kiick. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Li, Linqing
Kiick, Kristi L.
Transient dynamic mechanical properties of resilin-based elastomeric hydrogels
title Transient dynamic mechanical properties of resilin-based elastomeric hydrogels
title_full Transient dynamic mechanical properties of resilin-based elastomeric hydrogels
title_fullStr Transient dynamic mechanical properties of resilin-based elastomeric hydrogels
title_full_unstemmed Transient dynamic mechanical properties of resilin-based elastomeric hydrogels
title_short Transient dynamic mechanical properties of resilin-based elastomeric hydrogels
title_sort transient dynamic mechanical properties of resilin-based elastomeric hydrogels
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009447/
https://www.ncbi.nlm.nih.gov/pubmed/24809044
http://dx.doi.org/10.3389/fchem.2014.00021
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