Cargando…
Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial
Background: Based on classical two-cell, two-gonadotropin theory, in the follicle, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) put on their main effects on the granulosa and theca cells. LH is essential for androgens production. Androgens are used for estradiol production by gran...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research and Clinical Center for Infertility
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009563/ https://www.ncbi.nlm.nih.gov/pubmed/24799868 |
_version_ | 1782479768681185280 |
---|---|
author | Razi, Mohammad-Hossein Mohseni, Fereshteh Dehghani Firouzabadi, Razieh Janati, Sima Yari, Nahid Etebary, Sahabeh |
author_facet | Razi, Mohammad-Hossein Mohseni, Fereshteh Dehghani Firouzabadi, Razieh Janati, Sima Yari, Nahid Etebary, Sahabeh |
author_sort | Razi, Mohammad-Hossein |
collection | PubMed |
description | Background: Based on classical two-cell, two-gonadotropin theory, in the follicle, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) put on their main effects on the granulosa and theca cells. LH is essential for androgens production. Androgens are used for estradiol production by granulosa cells. Profound suppression of LH concentrations in some normogonadotropic patients can cause several adverse effects. Objective: The main clinical purpose of this study was that normoresponder women treated with controlled ovarian super ovulation for IVF or ICSI may benefit from co-administration of rLH. Materials and Methods: 40 patients who were candidates for assisted reproductive technology (ART) were randomly selected. In all patients long luteal protocol was used for ovulation induction. Patients were randomly divided into two groups: Group 1 (n=20) with standard long protocol (GnRH agonist) and r-FSH alone, Group 2 (n=20) with standard long protocol (GnRH agonist) and r-FSH with r-LH. Results were statistically analyzed and compared in two groups. Results: The number of retrieved oocytes, mature oocytes, cleaved embryos, transferred embryos, estradiol levels in Human chorionic gonadotropin (hCG) administration day, implantation rate and clinical pregnancy rate in group 2 were higher but not significantly different. Conclusion: Administration of rLH in late follicular phase had no beneficial effect on outcomes in young women with mean age of 31 years. Maybe a greater sample size should be used to see the effects more accurately; also it is possible that rLH will be useful in older patients. Registration ID in IRCT: IRCT201304302575N4 |
format | Online Article Text |
id | pubmed-4009563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Research and Clinical Center for Infertility |
record_format | MEDLINE/PubMed |
spelling | pubmed-40095632014-05-05 Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial Razi, Mohammad-Hossein Mohseni, Fereshteh Dehghani Firouzabadi, Razieh Janati, Sima Yari, Nahid Etebary, Sahabeh Iran J Reprod Med Original Article Background: Based on classical two-cell, two-gonadotropin theory, in the follicle, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) put on their main effects on the granulosa and theca cells. LH is essential for androgens production. Androgens are used for estradiol production by granulosa cells. Profound suppression of LH concentrations in some normogonadotropic patients can cause several adverse effects. Objective: The main clinical purpose of this study was that normoresponder women treated with controlled ovarian super ovulation for IVF or ICSI may benefit from co-administration of rLH. Materials and Methods: 40 patients who were candidates for assisted reproductive technology (ART) were randomly selected. In all patients long luteal protocol was used for ovulation induction. Patients were randomly divided into two groups: Group 1 (n=20) with standard long protocol (GnRH agonist) and r-FSH alone, Group 2 (n=20) with standard long protocol (GnRH agonist) and r-FSH with r-LH. Results were statistically analyzed and compared in two groups. Results: The number of retrieved oocytes, mature oocytes, cleaved embryos, transferred embryos, estradiol levels in Human chorionic gonadotropin (hCG) administration day, implantation rate and clinical pregnancy rate in group 2 were higher but not significantly different. Conclusion: Administration of rLH in late follicular phase had no beneficial effect on outcomes in young women with mean age of 31 years. Maybe a greater sample size should be used to see the effects more accurately; also it is possible that rLH will be useful in older patients. Registration ID in IRCT: IRCT201304302575N4 Research and Clinical Center for Infertility 2014-02 /pmc/articles/PMC4009563/ /pubmed/24799868 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Razi, Mohammad-Hossein Mohseni, Fereshteh Dehghani Firouzabadi, Razieh Janati, Sima Yari, Nahid Etebary, Sahabeh Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial |
title | Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial |
title_full | Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial |
title_fullStr | Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial |
title_full_unstemmed | Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial |
title_short | Results from adding recombinant LH for assisted reproductive technology treatment: A randomized control trial |
title_sort | results from adding recombinant lh for assisted reproductive technology treatment: a randomized control trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009563/ https://www.ncbi.nlm.nih.gov/pubmed/24799868 |
work_keys_str_mv | AT razimohammadhossein resultsfromaddingrecombinantlhforassistedreproductivetechnologytreatmentarandomizedcontroltrial AT mohsenifereshteh resultsfromaddingrecombinantlhforassistedreproductivetechnologytreatmentarandomizedcontroltrial AT dehghanifirouzabadirazieh resultsfromaddingrecombinantlhforassistedreproductivetechnologytreatmentarandomizedcontroltrial AT janatisima resultsfromaddingrecombinantlhforassistedreproductivetechnologytreatmentarandomizedcontroltrial AT yarinahid resultsfromaddingrecombinantlhforassistedreproductivetechnologytreatmentarandomizedcontroltrial AT etebarysahabeh resultsfromaddingrecombinantlhforassistedreproductivetechnologytreatmentarandomizedcontroltrial |