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Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats

Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water,...

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Autores principales: Amirshahi, Tayebeh, Najafi, Gholamreza, Nejati, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009575/
https://www.ncbi.nlm.nih.gov/pubmed/24799882
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author Amirshahi, Tayebeh
Najafi, Gholamreza
Nejati, Vahid
author_facet Amirshahi, Tayebeh
Najafi, Gholamreza
Nejati, Vahid
author_sort Amirshahi, Tayebeh
collection PubMed
description Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. Objective: The aim of present study was to evaluate protective effect of royal jelly on sperm parameters and malondialdehyde (MDA) production in rat. Materials and Methods: Forty adult male wistar rats (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat(. Royal Jelly group (RJG) received jelly (100 mg/kg daily) for 48 days orally. Bleomycin group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. Royal Jelly+ Bleomycin group (RJ+BLG) received royal Jelly (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum testosterone and MDA concentrations were measured as well. Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as testosterone concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. Royal jelly improved Bleomycin-induced toxicity on sperm parameters and testosterone and MDA concentrations. Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters. This article extracted from M.Sc. thesis. (Tayebeh amirshahi)
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spelling pubmed-40095752014-05-05 Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats Amirshahi, Tayebeh Najafi, Gholamreza Nejati, Vahid Iran J Reprod Med Original Article Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. Objective: The aim of present study was to evaluate protective effect of royal jelly on sperm parameters and malondialdehyde (MDA) production in rat. Materials and Methods: Forty adult male wistar rats (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat(. Royal Jelly group (RJG) received jelly (100 mg/kg daily) for 48 days orally. Bleomycin group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. Royal Jelly+ Bleomycin group (RJ+BLG) received royal Jelly (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum testosterone and MDA concentrations were measured as well. Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as testosterone concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. Royal jelly improved Bleomycin-induced toxicity on sperm parameters and testosterone and MDA concentrations. Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters. This article extracted from M.Sc. thesis. (Tayebeh amirshahi) Research and Clinical Center for Infertility 2014-03 /pmc/articles/PMC4009575/ /pubmed/24799882 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Amirshahi, Tayebeh
Najafi, Gholamreza
Nejati, Vahid
Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
title Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
title_full Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
title_fullStr Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
title_full_unstemmed Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
title_short Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
title_sort protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009575/
https://www.ncbi.nlm.nih.gov/pubmed/24799882
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