Cargando…
Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats
Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water,...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research and Clinical Center for Infertility
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009575/ https://www.ncbi.nlm.nih.gov/pubmed/24799882 |
_version_ | 1782479771405385728 |
---|---|
author | Amirshahi, Tayebeh Najafi, Gholamreza Nejati, Vahid |
author_facet | Amirshahi, Tayebeh Najafi, Gholamreza Nejati, Vahid |
author_sort | Amirshahi, Tayebeh |
collection | PubMed |
description | Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. Objective: The aim of present study was to evaluate protective effect of royal jelly on sperm parameters and malondialdehyde (MDA) production in rat. Materials and Methods: Forty adult male wistar rats (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat(. Royal Jelly group (RJG) received jelly (100 mg/kg daily) for 48 days orally. Bleomycin group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. Royal Jelly+ Bleomycin group (RJ+BLG) received royal Jelly (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum testosterone and MDA concentrations were measured as well. Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as testosterone concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. Royal jelly improved Bleomycin-induced toxicity on sperm parameters and testosterone and MDA concentrations. Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters. This article extracted from M.Sc. thesis. (Tayebeh amirshahi) |
format | Online Article Text |
id | pubmed-4009575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Research and Clinical Center for Infertility |
record_format | MEDLINE/PubMed |
spelling | pubmed-40095752014-05-05 Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats Amirshahi, Tayebeh Najafi, Gholamreza Nejati, Vahid Iran J Reprod Med Original Article Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. Objective: The aim of present study was to evaluate protective effect of royal jelly on sperm parameters and malondialdehyde (MDA) production in rat. Materials and Methods: Forty adult male wistar rats (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat(. Royal Jelly group (RJG) received jelly (100 mg/kg daily) for 48 days orally. Bleomycin group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. Royal Jelly+ Bleomycin group (RJ+BLG) received royal Jelly (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum testosterone and MDA concentrations were measured as well. Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as testosterone concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. Royal jelly improved Bleomycin-induced toxicity on sperm parameters and testosterone and MDA concentrations. Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters. This article extracted from M.Sc. thesis. (Tayebeh amirshahi) Research and Clinical Center for Infertility 2014-03 /pmc/articles/PMC4009575/ /pubmed/24799882 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Amirshahi, Tayebeh Najafi, Gholamreza Nejati, Vahid Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
title | Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
title_full | Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
title_fullStr | Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
title_full_unstemmed | Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
title_short | Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
title_sort | protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009575/ https://www.ncbi.nlm.nih.gov/pubmed/24799882 |
work_keys_str_mv | AT amirshahitayebeh protectiveeffectofroyaljellyonfertilityandbiochemicalparametersinbleomycininducedmalerats AT najafigholamreza protectiveeffectofroyaljellyonfertilityandbiochemicalparametersinbleomycininducedmalerats AT nejativahid protectiveeffectofroyaljellyonfertilityandbiochemicalparametersinbleomycininducedmalerats |