Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

The somatic mutation burden in healthy white blood cells (WBCs) is not well known. Based on deep whole-genome sequencing, we estimate that approximately 450 somatic mutations accumulated in the nonrepetitive genome within the healthy blood compartment of a 115-yr-old woman. The detected mutations ap...

Descripción completa

Detalles Bibliográficos
Autores principales: Holstege, Henne, Pfeiffer, Wayne, Sie, Daoud, Hulsman, Marc, Nicholas, Thomas J., Lee, Clarence C., Ross, Tristen, Lin, Jue, Miller, Mark A., Ylstra, Bauke, Meijers-Heijboer, Hanne, Brugman, Martijn H., Staal, Frank J.T., Holstege, Gert, Reinders, Marcel J.T., Harkins, Timothy T., Levy, Samuel, Sistermans, Erik A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009603/
https://www.ncbi.nlm.nih.gov/pubmed/24760347
http://dx.doi.org/10.1101/gr.162131.113

Ejemplares similares

Ejemplares similares