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Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?

BACKGROUND: There is a growing interest in better defining risk factors associated with increased susceptibility to exacerbation in patients with COPD. INTRODUCTION: The aim of the study was to determine whether identification of a respiratory virus during a severe acute exacerbation of COPD (AECOPD...

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Autores principales: Kherad, Omar, Bridevaux, Pierre-Olivier, Kaiser, Laurent, Janssens, Jean-Paul, Rutschmann, Olivier T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009736/
https://www.ncbi.nlm.nih.gov/pubmed/24799967
http://dx.doi.org/10.2174/1874306401408010018
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author Kherad, Omar
Bridevaux, Pierre-Olivier
Kaiser, Laurent
Janssens, Jean-Paul
Rutschmann, Olivier T.
author_facet Kherad, Omar
Bridevaux, Pierre-Olivier
Kaiser, Laurent
Janssens, Jean-Paul
Rutschmann, Olivier T.
author_sort Kherad, Omar
collection PubMed
description BACKGROUND: There is a growing interest in better defining risk factors associated with increased susceptibility to exacerbation in patients with COPD. INTRODUCTION: The aim of the study was to determine whether identification of a respiratory virus during a severe acute exacerbation of COPD (AECOPD) increases the risk of subsequent exacerbations and mortality during a one-year followup. METHODS: Secondary analysis of 86 COPD patients admitted for AECOPD between June 2007 and December 2008 at Geneva’s University Hospital who were followed up for 1 year. Fifty-one percent of index AECOPD were related to viral infection. Rate of AECOPD, time to next AECOPD, and all-cause mortality were compared between patients with vs without viral index AECOPD. RESULTS: Eighty-one cases were included in this secondary follow-up analysis. Mean exacerbation rate was 1.9 AECOPD per person-year for patients with viral index AECOPD vs 4.0 AECOPD per person year for those with non-viral index AECOPD. Incidence rate ratio (IRR) for subsequent AECOPD during one year follow up was lower for patients with viral index AECOPD (IRR 0.57; [CI 95% 0.39-0.84]), after controlling for previous exacerbations, and was strongly associated with the number of exacerbations in the year preceding the index AECOPD. During the one-year follow-up period, 16 patients (19%) died. In a Cox regression model, patients with a proven viral infection did not have a higher mortality (HR 0.56 [CI 95% 0.20 -1.58]). CONCLUSION: Viral AECOPD was not associated with a higher rate of subsequent exacerbations or mortality during the following year.
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spelling pubmed-40097362014-05-05 Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate? Kherad, Omar Bridevaux, Pierre-Olivier Kaiser, Laurent Janssens, Jean-Paul Rutschmann, Olivier T. Open Respir Med J Article BACKGROUND: There is a growing interest in better defining risk factors associated with increased susceptibility to exacerbation in patients with COPD. INTRODUCTION: The aim of the study was to determine whether identification of a respiratory virus during a severe acute exacerbation of COPD (AECOPD) increases the risk of subsequent exacerbations and mortality during a one-year followup. METHODS: Secondary analysis of 86 COPD patients admitted for AECOPD between June 2007 and December 2008 at Geneva’s University Hospital who were followed up for 1 year. Fifty-one percent of index AECOPD were related to viral infection. Rate of AECOPD, time to next AECOPD, and all-cause mortality were compared between patients with vs without viral index AECOPD. RESULTS: Eighty-one cases were included in this secondary follow-up analysis. Mean exacerbation rate was 1.9 AECOPD per person-year for patients with viral index AECOPD vs 4.0 AECOPD per person year for those with non-viral index AECOPD. Incidence rate ratio (IRR) for subsequent AECOPD during one year follow up was lower for patients with viral index AECOPD (IRR 0.57; [CI 95% 0.39-0.84]), after controlling for previous exacerbations, and was strongly associated with the number of exacerbations in the year preceding the index AECOPD. During the one-year follow-up period, 16 patients (19%) died. In a Cox regression model, patients with a proven viral infection did not have a higher mortality (HR 0.56 [CI 95% 0.20 -1.58]). CONCLUSION: Viral AECOPD was not associated with a higher rate of subsequent exacerbations or mortality during the following year. Bentham Open 2014-04-04 /pmc/articles/PMC4009736/ /pubmed/24799967 http://dx.doi.org/10.2174/1874306401408010018 Text en © Kherad et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Kherad, Omar
Bridevaux, Pierre-Olivier
Kaiser, Laurent
Janssens, Jean-Paul
Rutschmann, Olivier T.
Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?
title Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?
title_full Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?
title_fullStr Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?
title_full_unstemmed Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?
title_short Is Acute Exacerbation of COPD (AECOPD) Related to Viral Infection Associated with Subsequent Mortality or Exacerbation Rate?
title_sort is acute exacerbation of copd (aecopd) related to viral infection associated with subsequent mortality or exacerbation rate?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009736/
https://www.ncbi.nlm.nih.gov/pubmed/24799967
http://dx.doi.org/10.2174/1874306401408010018
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