Hepatitis C Virus and Hepatocellular Carcinoma

Hepatitis C virus (HCV), a hepatotropic virus, is a single stranded-positive RNA virus of ~9,600 nt. length belonging to the Flaviviridae family. HCV infection causes acute hepatitis, chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that HCV-coding proteins inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanda, Tatsuo, Yokosuka, Osamu, Omata, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009856/
https://www.ncbi.nlm.nih.gov/pubmed/24832662
http://dx.doi.org/10.3390/biology2010304
_version_ 1782479815482277888
author Kanda, Tatsuo
Yokosuka, Osamu
Omata, Masao
author_facet Kanda, Tatsuo
Yokosuka, Osamu
Omata, Masao
author_sort Kanda, Tatsuo
collection PubMed
description Hepatitis C virus (HCV), a hepatotropic virus, is a single stranded-positive RNA virus of ~9,600 nt. length belonging to the Flaviviridae family. HCV infection causes acute hepatitis, chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that HCV-coding proteins interact with host-cell factors that are involved in cell cycle regulation, transcriptional regulation, cell proliferation and apoptosis. Severe inflammation and advanced liver fibrosis in the liver background are also associated with the incidence of HCV-related HCC. In this review, we discuss the mechanism of hepatocarcinogenesis in HCV-related liver diseases.
format Online
Article
Text
id pubmed-4009856
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-40098562014-05-07 Hepatitis C Virus and Hepatocellular Carcinoma Kanda, Tatsuo Yokosuka, Osamu Omata, Masao Biology (Basel) Review Hepatitis C virus (HCV), a hepatotropic virus, is a single stranded-positive RNA virus of ~9,600 nt. length belonging to the Flaviviridae family. HCV infection causes acute hepatitis, chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that HCV-coding proteins interact with host-cell factors that are involved in cell cycle regulation, transcriptional regulation, cell proliferation and apoptosis. Severe inflammation and advanced liver fibrosis in the liver background are also associated with the incidence of HCV-related HCC. In this review, we discuss the mechanism of hepatocarcinogenesis in HCV-related liver diseases. MDPI 2013-01-30 /pmc/articles/PMC4009856/ /pubmed/24832662 http://dx.doi.org/10.3390/biology2010304 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kanda, Tatsuo
Yokosuka, Osamu
Omata, Masao
Hepatitis C Virus and Hepatocellular Carcinoma
title Hepatitis C Virus and Hepatocellular Carcinoma
title_full Hepatitis C Virus and Hepatocellular Carcinoma
title_fullStr Hepatitis C Virus and Hepatocellular Carcinoma
title_full_unstemmed Hepatitis C Virus and Hepatocellular Carcinoma
title_short Hepatitis C Virus and Hepatocellular Carcinoma
title_sort hepatitis c virus and hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009856/
https://www.ncbi.nlm.nih.gov/pubmed/24832662
http://dx.doi.org/10.3390/biology2010304
work_keys_str_mv AT kandatatsuo hepatitiscvirusandhepatocellularcarcinoma
AT yokosukaosamu hepatitiscvirusandhepatocellularcarcinoma
AT omatamasao hepatitiscvirusandhepatocellularcarcinoma

Ejemplares similares