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BRCA1 and Its Network of Interacting Partners
BRCA1 is a large multi-domain protein with a pivotal role in maintaining genome stability and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated lifetime risk of 60%–80% for breast cancer and 15%–60% for ovarian cancer. Many of the germline mutations associated with can...
Autores principales: | Christou, Charita M., Kyriacou, Kyriacos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009870/ https://www.ncbi.nlm.nih.gov/pubmed/24832651 http://dx.doi.org/10.3390/biology2010040 |
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